Cetirizine

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Cetirizine
Systematic (IUPAC) name
(±)-[2-[4-[(4-chlorophenyl)phenylmethyl]-1- piperazinyl]ethoxy]acetic acid
Clinical data
Trade namesZyrtec
AHFS/Drugs.commonograph
MedlinePlusa698026
Licence dataUS FDA:link
Pregnancy cat.B (US)
Legal statusGSL (UK) OTC (US) OTC in Canada
RoutesOral
Pharmacokinetic data
Bioavailabilitywell absorbed
Protein binding~93%
MetabolismExcreted mainly unchanged
Half-life8.3 Hours
ExcretionUrine (mainly), hepatic or excrement (Small amounts)
Identifiers
CAS number83881-51-0 YesY
ATC codeR06AE07
PubChemCID 2678
IUPHAR ligand1222
DrugBankDB00341
ChemSpider2577 YesY
UNIIYO7261ME24 YesY
KEGGD07662 YesY
ChEBICHEBI:3561 YesY
ChEMBLCHEMBL1000 YesY
SynonymsAlerid, Alatrol, Alzene, Cetirizina, Cetirin, Cetzine, Cetirizin, Cezin, Histazine, Humex, Letizen, Razene, Reactine, Zyrtec, Zirtec, Zodac, Zirtek, Zynor, Zyrlek, Zyllergy
Chemical data
FormulaC21H25ClN2O3 
Mol. mass388.89
 YesY (what is this?)  (verify)
 
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Cetirizine
Systematic (IUPAC) name
(±)-[2-[4-[(4-chlorophenyl)phenylmethyl]-1- piperazinyl]ethoxy]acetic acid
Clinical data
Trade namesZyrtec
AHFS/Drugs.commonograph
MedlinePlusa698026
Licence dataUS FDA:link
Pregnancy cat.B (US)
Legal statusGSL (UK) OTC (US) OTC in Canada
RoutesOral
Pharmacokinetic data
Bioavailabilitywell absorbed
Protein binding~93%
MetabolismExcreted mainly unchanged
Half-life8.3 Hours
ExcretionUrine (mainly), hepatic or excrement (Small amounts)
Identifiers
CAS number83881-51-0 YesY
ATC codeR06AE07
PubChemCID 2678
IUPHAR ligand1222
DrugBankDB00341
ChemSpider2577 YesY
UNIIYO7261ME24 YesY
KEGGD07662 YesY
ChEBICHEBI:3561 YesY
ChEMBLCHEMBL1000 YesY
SynonymsAlerid, Alatrol, Alzene, Cetirizina, Cetirin, Cetzine, Cetirizin, Cezin, Histazine, Humex, Letizen, Razene, Reactine, Zyrtec, Zirtec, Zodac, Zirtek, Zynor, Zyrlek, Zyllergy
Chemical data
FormulaC21H25ClN2O3 
Mol. mass388.89
 YesY (what is this?)  (verify)

Cetirizine /sɛˈtɪrɨzn/ is a second-generation[1] antihistamine used in the treatment of allergies, hay fever, angioedema, and urticaria. It is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist.

Availability[edit source | edit]

Cetirizine10.JPG

Formerly prescription-only in the USA and Canada, cetirizine is now available over-the-counter in both countries[2] as Zyrtec and Reactine, respectively. Zyrtec was the highest-grossing new non-food product of 2008 in the US, generating sales of $315.9 million.[3] It is also available as a generic drug. In Turkey, Australia and New Zealand, Zyrtec is available over-the-counter in pharmacies and in the UK cetirizine can be sold in limited quantities off-the-shelf in any outlet and is often available in supermarkets. As of 2009, Germany made many generic drugs containing cetirizine available in pharmacies without prescription.[4] Norway, Sweden,[5] Finland, Poland and Israel also recognize Cetirizine as an over-the-counter medicine. In India, it is sold over-the-counter as brand-name "CTZ" (formerly called "Cetzine"), even though it remains classified as a Schedule H (prescription) drug.[6] India also classifies Cetirizine as an OTC drug, and uses it as an alternative to Pheniramine (Avil) which is no longer provided OTC in India.

Pharmacology[edit source | edit]

Cetirizine crosses the blood–brain barrier only slightly, reducing the sedative side-effect common with older antihistamines.[7] It has also been shown to inhibit eosinophil chemotaxis and LTB4 release. At a dosage of 20 mg, Boone et al. found that it inhibited the expression of VCAM-1 in patients with atopic dermatitis.[8] Unlike many other antihistamines, Cetirizine does not exhibit anticholinergic properties.[9]

The levorotary enantiomer of cetirizine, known as levocetirizine, is the more active form.

L-Stereoisomer, levocetirizine (top) and D-stereoisomer of cetirizine

Administration method and metabolism[edit source | edit]

Chewable, non-chewable, and syrup forms of cetirizine are similarly absorbed rapidly and effectively, with absorbed food minutely affecting the absorption rate which yields a peak serum level one hour after administration;[10] in a study of healthy volunteers prescribed 10 mg tablets, once daily for 10 days, a mean peak serum level of 311 ng/mL was observed.[11] The metabolic effects of cetirizine are long acting, remaining in the system for a maximum of 21 hours before being excreted; the average elimination half-life is 8 hours. About 70% of the drug is removed through urination, of which half is observed as unchanged cetirizine compound. Another 10% is excreted.[10][11]

Like many other antihistamine medications, cetirizine is commonly prescribed in combination with pseudoephedrine hydrochloride, a decongestant. These combinations are marketed using the same brand name as the cetirizine with a "-D" suffix (Zyrtec-D, Virlix-D, etc.)

Indications[edit source | edit]

Allergies[edit source | edit]

Cetirizine's primary indication is for hay fever and other allergies. Because the symptoms of itching and redness in these conditions are caused by histamine acting on the H1 receptor, blocking those receptors temporarily relieves those symptoms.

Rhinovirus infection[edit source | edit]

Interleukin 6 and interleukin 8 have been shown to be elevated in acute respiratory distress syndrome.[12] Cetirizine contains L- and D-stereoisomers. Chemically, levocetirizine is the active L-enantiomer of cetirizine. One recent study of airway epithelial cells showed that Levocetirizine may have beneficial effects on the pathophysiologic changes related to human rhinovirus (HRV) infection.[13] Airway inflammation caused from a cytokine storm secondary to acute respiratory distress syndrome could also theoretically benefit.

Kimura's disease[edit source | edit]

Cetirizine is an effective agent in treating the symptoms of Kimura's disease, which mostly occurs in young Asian men, affecting the lymph nodes and soft tissue of the head and neck in the form of tumor-like lesions. Cetirizine's properties of being effective both in the treatment of pruritus (itching) and as an anti-inflammatory agent make it suitable for the treatment of the pruritus associated with these lesions.[14] In a 2005 study, the American College of Rheumatology conducted treatments initially using prednisone, followed by steroid dosages and azathioprine, omeprazole, and calcium and vitamin D supplements over the course of two years.[14] The skin condition of the patient began to improve and the skin lesions lessened. However, there were symptoms of cushingoid and hirsutism observed before the patient was removed from the courses of steroids and placed on 10 mg/day of cetirizine to prevent skin lesions;[14] an agent suitable for the treatment of pruritus associated with such lesions.[14] Asymptomatically, the patient's skin lesions disappeared after treatment with cetirizine, blood eosinophil counts became normal,[14] corticosteroid effects were resolved,[14] and a remission began within a period of two months.[14] It is also thought that the inhibition of eosinophils may be the key to treatment of Kimura's disease due to the role of eosinophils, rather than other cells with regards to the lesions of the skin.[14]

Side effects[edit source | edit]

Dryness of the mouth, nose and throat, drowsiness, urinary retention, blurred vision, nightmares and stomach ache are commonly reported side effects of this drug.[15] Cetirizine does not block the action of the muscarinic acetylcholine receptors, even though these side effects can occur in some patients. Also, cetirizine does not have antidopaminergic properties. In 2012, the FDA added cetirizine in Drugs to Watch List for oculogyric crisis.[16]

Synthesis[edit source | edit]

The following synthesis of this compound was reported in 1985:[17]

Cetirizine synthesis.png

References[edit source | edit]

  1. ^ http://www.medscape.com/viewarticle/561316
  2. ^ Payne, January W (2008-01-09). "Over-the-Counter Zyrtec: a Money-Saver?". U.S. News & World Report. 
  3. ^ Elliott, Stuart (24 March 2009). "A Strategy When Times Are Tough: "It's New!"". The New York Times. Retrieved 26 March 2009. 
  4. ^ "Cetirizin". 
  5. ^ "Cetirizin". 
  6. ^ Drugs and Cosmetics (2nd amendment) rules, 2006. item 104 in schedule H.
  7. ^ Gupta, A; Chatelain P, Massingham R, Jonsson EN, Hammarlund-Udenaes M (February 2006). "Brain distribution of cetirizine enantiomers: comparison of three different tissue-to-plasma partition coefficients: K(p), K(p,u), and K(p,uu)". Drug Metab. Dispos. 34 (2): 318–23. doi:10.1124/dmd.105.007211. PMID 16303872. 
  8. ^ Boone M, Lespagnard L, Renard N, Song M, Rihoux JP (July 2000). "Adhesion molecule profiles in atopic dermatitis vs. allergic contact dermatitis: pharmacological modulation by cetirizine". J Eur Acad Dermatol Venereol 14 (4): 263–6. doi:10.1046/j.1468-3083.2000.00017.x. PMID 11204513. Retrieved 2009-11-19. 
  9. ^ Orzechowski, RF; DS Currie, CA Valancius (4). "Comparative anticholinergic activities of 10 histamine H1 receptor antagonists in two functional models.". European Journal of Pharmacology 506 (3): 257–264. Retrieved 4 July 2013. 
  10. ^ a b Anderson, Philip; Knoben, James E.; Troutman, William G. (2002). Handbook of clinical drug data. New York: McGraw-Hill. p. 807. ISBN 0-07-136362-9.  |accessdate= requires |url= (help)
  11. ^ a b "Zyrtec prescribing information". May 2006. Retrieved 2009-11-19. 
  12. ^ Chollet-Martin, S; Montravers, P; Gibert, C; Elbim, C; Desmonts, JM; Fagon, JY; Gougerot-Pocidalo, MA (1993). "High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome". Infection and immunity 61 (11): 4553–9. PMC 281204. PMID 8406851. 
  13. ^ Jang YJ, Wang JH, Kim JS, Kwon HJ, Yeo NK, Lee BJ (March 2009). "Levocetirizine inhibits rhinovirus-induced ICAM-1 and cytokine expression and viral replication in airway epithelial cells". Antiviral Res. 81 (3): 226–33. doi:10.1016/j.antiviral.2008.12.001. PMID 19110001. 
  14. ^ a b c d e f g h Ben-Chetrit E, Amir G, Shalit M (February 2005). "Cetirizine: An effective agent in Kimura's disease". Arthritis Rheum. 53 (1): 117–8. doi:10.1002/art.20908. PMID 15696573. 
  15. ^ British National Formulary (BNF) 61. 2011. 
  16. ^ http://www.medscape.com/viewarticle/773081?src=mp
  17. ^ US patent 4525358, Baltes E, De Lannoy J, Rodriguez L, "2-[4-(Diphenylmethyl)-1-piperazinyl]-acetic acids and their amides", issued 1985-06-25, assigned to UCB Pharmaceuticals, Inc 

Books and journals[edit source | edit]

  1. Anderson, P. O., Knoben, J. E., et al. (2002) Handbook of clinical drug data 10th ed. McGraw-Hill International
  2. Pfizer Inc, et al. (2006) ZYRTEC (cetirizine hydrochloride) Tablets, Chewable Tablets and Syrup For Oral Use Pfizer Incorporated publications
  3. Chetrit, E. B., Amir, G., Shalit, M. (2005). Cetirizine: an effective agent in Kimura's Disease Arthritis & Rheumatism (Arthritis care & research) Vol 53, p117-118

External links[edit source | edit]