5'-3' exoribonuclease 2

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5'-3' exoribonuclease 2
Identifiers
SymbolXRN2
External IDsOMIM608851 MGI894687 HomoloGene6927 GeneCards: XRN2 Gene
EC number3.1.13.-
Orthologs
SpeciesHumanMouse
Entrez2280324128
EnsemblENSG00000088930ENSMUSG00000027433
UniProtQ9H0D6Q9DBR1
RefSeq (mRNA)NM_012255NM_011917
RefSeq (protein)NP_036387NP_036047
Location (UCSC)Chr 20:
21.28 – 21.37 Mb
Chr 2:
147.01 – 147.08 Mb
PubMed search[1][2]
 
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5'-3' exoribonuclease 2
Identifiers
SymbolXRN2
External IDsOMIM608851 MGI894687 HomoloGene6927 GeneCards: XRN2 Gene
EC number3.1.13.-
Orthologs
SpeciesHumanMouse
Entrez2280324128
EnsemblENSG00000088930ENSMUSG00000027433
UniProtQ9H0D6Q9DBR1
RefSeq (mRNA)NM_012255NM_011917
RefSeq (protein)NP_036387NP_036047
Location (UCSC)Chr 20:
21.28 – 21.37 Mb
Chr 2:
147.01 – 147.08 Mb
PubMed search[1][2]

5'-3' Exoribonuclease 2 (XRN2) also known as DHM1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene.[1]

The human gene encoding XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 genes. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1.

Function[edit]

Human XRN2 is involved in the torpedo model of transcrption termination.[2]

The C. elegans homologue, XRN-2, is involved in the degradation of certain mature miRNAs and their dislodging from miRISC miRNAs.[3]

References[edit]

  1. ^ Zhang M, Yu L, Xin Y, Hu P, Fu Q, Yu C, Zhao S (July 1999). "Cloning and mapping of the XRN2 gene to human chromosome 20p11.1-p11.2". Genomics 59 (2): 252–4. doi:10.1006/geno.1999.5866. PMID 10409438. 
  2. ^ West S, Gromak N, Proudfoot NJ (November 2004). "Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites". Nature 432 (7016): 522–5. doi:10.1038/nature03035. PMID 15565158. 
  3. ^ Chatterjee S, Grosshans H (September 2009). "Active turnover modulates mature microRNA activity in Caenorhabditis elegans". Nature 461 (7263): 546–9. doi:10.1038/nature08349. PMID 19734881. 

Further reading[edit]

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