Vulvar intraepithelial neoplasia

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Vulvar intraepithelial neoplasia
Classification and external resources

Micrograph of (classic) vulvar intraepithelial neoplasia III. H&E stain.
ICD-10D07.1 (ILDS D07.120)
ICD-9233.32
 
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Vulvar intraepithelial neoplasia
Classification and external resources

Micrograph of (classic) vulvar intraepithelial neoplasia III. H&E stain.
ICD-10D07.1 (ILDS D07.120)
ICD-9233.32

The term Vulvar intraepithelial neoplasia (VIN) refers to particular changes that can occur in the skin that covers the vulva. VIN is not cancer, and in some women it disappears without treatment. If the changes become more severe, there is a chance that cancer might develop after many years, and so it is referred to as a precancerous condition.[1]

ISSVD Classification[edit source | edit]

Medically speaking, the term denotes a squamous intraepithelial lesion of the vulva that shows dysplasia with varying degrees of atypia. The epithelial basement membrane is intact and the lesion is thus not invasive but has invasive potential.

The terminology of VIN evolved over several decades. In 1989[2] the Committee on Terminology, International Society for the Study of Vulvar Disease (ISSVD) replaced older terminology such as vulvar dystrophy, Bowen's disease, and Kraurosis vulvae by a new classification system for Epithelial Vulvar Disease:

The ISSVD further revised this classification in 2004, replacing the three-grade system with a single-grade system in which only the high-grade disease is classified as VIN. This is subdivided into: 1) usual-type VIN (including warty, basaloid and mixed subtypes)commonly associated with carcinogenic genotypes of HPV and/or HPV persistence factors such as cigarette smoking or immunocompromised states and 2) differentiated VIN, commonly associated with vulvar dermatoses such as lichen sclerosis. Differentiated VIN associated with lichen sclerosis, however, is more likely to be associated with squamous carcinoma than is usual-type VIN.

Flat lesions with basal atypia (formerly VIN I) are considered condylomas and can be treated as such.[3]

Causes[edit source | edit]

The exact cause of VIN is unknown. Studies are being done to determine the cause of VIN. The following factors have been associated with VIN:
• HPV Human Papilloma Virus)
• HSV-2 (Herpes simplex Virus - Type 2)
• Smoking
• Immunosuppression
• Chronic vulvar irritation
• Conditions such as Lichen Sclerosus

Diagnosis[edit source | edit]

Micrograph of vulvar intraepithelial neoplasia III. H&E stain.
Micrograph of differentiated vulvar intraepithelial neoplasia. H&E stain.

The patient may have no symptoms, or local symptomatology including itching, burning, and pain. The diagnosis is always based on a careful inspection and a targeted biopsy.

Prevention[edit source | edit]

Vaccinating girls with HPV vaccine before their initial sexual contact has been claimed to reduce incidence of VIN.[4]

Treatment[edit source | edit]

The treatment of VIN is local to wide excision, in case of very extensive involvement or recurrency even a simple vulvectomy. Laser therapy has also been useful for VIN.

Additional images[edit source | edit]

References[edit source | edit]

  1. ^ "Vulval intra-epithelial neoplasia (VIN)". Macmillan Cancer Support. Retrieved 2010-06-09. 
  2. ^ Ridley CM, Frankman O, Jones IS, et al. (May 1989). "New nomenclature for vulvar disease: International Society for the Study of Vulvar Disease". Hum. Pathol. 20 (5): 495–6. doi:10.1016/0046-8177(89)90019-1. PMID 2707802. 
  3. ^ Committee Opinion No.509, American College of Obstetricians and Gynecologists. Obstet Gynecol 2011; 118:1192-4.
  4. ^ "FDA Approves Expanded Uses for Gardasil to Include Preventing Certain Vulvar and Vaginal Cancers". 2008-09-12. Retrieved 2010-02-13. 

External links[edit source | edit]