In 2001 Iacopino wrote a manual on recognizing and treating torture victims for the United Nations.
Iacopino published a paper entitled “Neglect of Medical Evidence of Torture in Guantánamo Bay: A Case Series” in April 2011.
On February 5, 2013, Iacopino testified, by video link, at the Guantanamo Military Commission in the case of Abd al Rahim al Nashiri who is accused of involvement in the USS Cole bombing. Iacopino was asked on how to conduct a no-harm medical examination on Nashiri who was subject of what is described as a mock execution and who was waterboarded by the CIA twice. On February 7, in response to a Prosecution request James Pohl, the Presiding Officer of al Nashiri's Military Commission ordered that a panel of mental health experts examine Al Nashiri. The Defense, in turn, argued that panel should take advice from Iacopino, on how to interview Al Nashiri without causing additional damage.
^Andy Worthington (2011-04-30). "Study Says Doctors At Guantánamo Neglected Or Concealed Evidence of Torture, Plus My Interview With Press TV – OpEd". Eurasia Review. Archived from the original on 2013-02-06. Retrieved 2013-02-06. "Just as WikiLeaks is revealing details of the regime of torture, coercion and bribery that was required to create what purported to be evidence at Guantánamo, the peer-reviewed journal journal PloS Medicine published a research article, “Neglect of Medical Evidence of Torture in Guantánamo Bay: A Case Series,” written by Vincent Iacopino, a senior medical advisor to Physicians for Human Rights, and Stephen Xenakis, a retired US Army Brigadier General, examining the cases of nine former prisoners, “all of whom,” as they say, “alleged torture and ill treatment during detention at the facility.”"
^Donna Miles (2013-02-07). "Mental Health Test Delays Cole Bombing Suspect Hearings". American Forces Press Service. Archived from the original on 2013-02-09. "Members of the defense questioned what such an assessment would provide, telling the commission judge, Army Col. James L. Pohl, they lack faith in any medical practitioner the convening authority might appoint to conduct it. Pohl authorized the exam, but granted the defense’s request that Dr. Vincent Iacopino, a member of the Physicians for Human Rights organization with expertise in torture, be called on to provide advice on how to conduct it without “doing harm.”"