Venomous snake

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"Poisonous snake" redirects here. For true poisonous snakes, see Rhabdophis.

Venomous snakes are species of suborder Serpentes that are capable of producing venom which is used primarily for immobilizing prey and defense mostly via mechanical injection by fangs. Common venomous snakes include Families Elapidae, Viperidae, Atractaspididae and some of Colubridae. The toxicity of them is mainly indicated by murine LD50, while multifarious factors are considered to judge their potential danger to humans.


The evolutionary history of venomous snakes can be traced back to as far as 25 million years ago.[1] Snake venom is actually modified saliva used for prey immobilization and self-defense and is usually delivered through highly specialized teeth, hollow fangs, directly into the bloodstream or tissue of the target. Evidence has recently been presented for the Toxicofera hypothesis, but venom was present (in small amounts) in the ancestors of all snakes (as well as several lizard families) as 'toxic saliva' and evolved to extremes in those snake families normally classified as venomous by parallel evolution. The Toxicofera hypothesis further implies that 'nonvenomous' snake lineages have either lost the ability to produce venom (but may still have lingering venom pseudogenes), or actually do produce venom in small quantities, likely sufficient enough to help capture small prey but causing no harm to humans when bitten.


There is no a single or special taxonomic group for venomous snakes which comprise species from different families. This has been interpreted to mean venom in snakes originated more than once as the result of convergent evolution. Around a quarter of all snake species are identified as being venomous.

Atractaspididae (atractaspidids)Burrowing asps, mole vipers, stiletto snakes
Colubridae (colubrids)Most are harmless, but others have potent venom and at least five species, including the boomslang (Dispholidus typus), have caused human fatalities.
Elapidae (elapids)Sea snakes, taipans, brown snakes, coral snakes, kraits, death adders, tiger snakes, mambas, king cobra and cobras
Viperidae (viperids)True vipers, including the Russell's viper, saw-scaled vipers, puff adders and pit vipers, including rattlesnakes, lanceheads and copperheads and cottonmouths.


Venomous snakes are often said to be poisonous, although this is not the correct term since venom and poison are different entities. Poisons are absorbed by the body, such as through skin or the digestive system, while venoms must first be introduced directly into tissues or the bloodstream (envenomated) by mechanical means. It is, for example, harmless to drink snake venom as long as there are no lacerations inside the mouth or digestive tract. The two exceptions are: the Rhabdophis keelback snakes secrete poison from glands they get from the poisonous toads they consume, and similarly, certain garter snakes from Oregon retain toxins in their livers from the newts they eat.[2]


The world's most venomous snake, based on LD50, is the inland taipan.

Toxicity issues[edit]

LD50, mostly on rodents, is a common indicator of snakes' toxicity whose level is higher with a smaller resultant value. There have been numerous studies on snake venom with a variability of potency estimates.[3] There are four methods in which the LD50 test is conducted, which are injections to subcutis (SC), vein (IV), muscle (IM or IC), and peritoneum (IP). The former (SC) is most applicable to actual bites as only vipers with large fangs, such as large Bitis, Bothrops or Crotalus specimens, would be able to deliver a bite that is truly intramuscular, and snakebites rarely cause IV envenomation. Testing using dry venom mixed with 0.1% bovine serum albumin in saline, gives more consistent results than just saline alone.

Studies on mice[4][5][6] and human cardiac cell culture[7][8][9] shows that venom of the inland taipan, drop by drop, is the most toxic among all snakes.

The world's most venomous snakes[10][11][12][13]
No corresponding IM/IC & IP data are given for the snakes below.
SnakeRegionSC (0.1% bovine serum albumin in Saline)SC (Saline alone)IV
Inland taipanAustralia0.01 mg/kg0.025 mg/kgN/A
Dubois' seasnakeCoral Sea, Arafura Sea, Timor Sea and Indian OceanN/A0.044 mg/kgN/A
Eastern brown snakeAustralia, Papua New Guinea, Indonesia0.041 mg/kg0.053 mg/kg0.01 mg/kg
Black MambaSub-Saharan Africa0.05 mg/kg0.12 mg/kg[11] - 0.32 mg/kgN/A
Coastal TaipanAustralia, Papua New Guinea0.064 mg/kg0.099 mg/kg0.013 mg/kg
Yellow bellied sea snakeTropical oceanic watersN/A0.067 mg/kgN/A
Peron's sea snakeGulf of Siam, Strait of Taiwan, Coral sea islands, and other placesN/A0.079 mg/kgN/A
Black Tiger snakeAustralia0.099 mg/kg0.131 mg/kgN/A
Many-banded kraitMainland China, Taiwan, Vietnam, Laos, Burma0.09 mg/kg0.108 mg/kg0.113 mg/kg
Black-banded sea kraiteastern coast of the Malay Peninsula and Brunei, and in Halmahera, Indonesia..N/A0.111 mg/kgN/A
Mainland Tiger snakeAustralia0.118 mg/kg0.118 mg/kg0.014 mg/kg
Western Australian Tiger snakeAustralia0.124 mg/kg0.194 mg/kgN/A
Beaked sea snakeTropical Indo-Pacific0.164 mg/kg0.1125 mg/kgN/A

Other factors[edit]

The Big Four snakes responsible for most fatal bites in India

Toxicity of snake venom is sometimes used to gauge the extent of their danger to humans, but this is inappropriate. Many venomous snakes are specialized predators of rodents whose venom may be adapted specifically to incapacitate mice.[14] A number of other factors are more critical in determining the potential hazard of any given venomous snake to humans, including the distribution and the behavior of them.[15][16] For example, while the inland taipan is regarded as the world's most venomous snake based on LD50, the "Big Four" snakes cause far more snakebites due to their proximity to populous areas. Clinical mortality rates, reflected by medical precedents, are another commonly used indicator to determine the danger of any given venomous snake, as determined by the efficiency of their venom delivery, venom yield and the behavior in response to humans. The black mamba and coastal taipan, for instance, can cause a 100% untreated mortality rate as tending to deliver bites with a fatal quantity of venom in every case.[17][18]

See also[edit]


  1. ^ Oldest fossil evidence of modern African venomous snakes found in Tanzania, Ohio University, March 20, 2014, doi:10.1371/journal.pone.0090415 
  2. ^ Klauber LM. (1997). Rattlesnakes: Their Habitats, Life Histories, and Influence on Mankind (2 ed.). Berkeley: University of California Press, Berkeley, 1956, 1972. ISBN 0-520-21056-5. 
  3. ^ Mackessy, Stephen P. (June 2002). "Biochemistry and pharmacology of colubrid snake venoms". Journal of Toxicology: Toxin Reviews 21 (1–2): 43–83. doi:10.1081/TXR-120004741. Retrieved 2009-09-26. 
  4. ^
  5. ^
  6. ^ Inland Taipan Venom vs. Sea Snakes Venom (most notable Belcher's sea snake)
  7. ^ Fry, Bryan (February 08, 2005) Most Venomous,"Q;I was wondering what snakes venom is the most potent to humans A:Drop for drop it is the inland taipan (Oxyuranus microlepidotus), which has a venom more toxic than any other land snake or even the sea snakes." Forums, Retrieved April 17, 2014
  8. ^ Seymour, Jamie, World's Worst Venom, (Min 44.33) "Among the reptiles tested, the most toxic venom belongs to inland taipan, killing over 60% of heart cells in the first 10 minutes" National Geographic Channel Retrieved April 17, 2014
  9. ^ Seymour, Jamie Venom deathmatch "They have the most toxic venom towards humans then any other snake in the world" (min 1:49) National Geographic Channel, Retrieved April 17, 2014
  10. ^ Zug, GR. (1996). Snakes in Question: The Smithsonian Answer Book. Washington D.C., US: Smithsonian Institution Scholarly Press. ISBN 1-56098-648-4. 
  11. ^ a b Brown, JH (1973). Toxicology and Pharmacology of Venoms from Poisonous Snakes. Springfield, Illinois: Charles C. Thomas. p. 184. ISBN 0-398-02808-7. 
  12. ^ Broad and Sutherland (1979). "The lethality in mice of dangerous Australian and other snake venom" 17. Toxicon. Retrieved October 13, 2014. 
  13. ^ Fry, B. "Snakes Venom LD50". Retrieved October 14, 2014. 
  14. ^ "What is an LD50 and LC50". 
  15. ^ "Most venomous snakes". Reptile Gardens. Retrieved October 13, 2014. 
  16. ^ Walls, Jerry G. "Deadly Snakes: What are the world's most deadly venomous snakes?". Reptiles (magazine). Retrieved November 5, 2013. 
  17. ^ Davidson, Terence. "IMMEDIATE FIRST AID - Black Mamba". University of California, San Diego. Retrieved 2010-05-12. 
  18. ^ "IMMEDIATE FIRST AID for bites by Australian taipan or common taipan". 

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