Trimix (injection)

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Trimix (injection)
Combination of
Alprostadilprostaglandin
Papaverinevasodilator
Phentolaminealpha blocker
Clinical data
Pregnancy cat.
Legal status
Routesgel, injection, topical
Identifiers
CAS number YesY
ATC code?
 YesY (what is this?)  (verify)
 
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Trimix (injection)
Combination of
Alprostadilprostaglandin
Papaverinevasodilator
Phentolaminealpha blocker
Clinical data
Pregnancy cat.
Legal status
Routesgel, injection, topical
Identifiers
CAS number YesY
ATC code?
 YesY (what is this?)  (verify)

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. The active ingredients in the mixture are usually alprostadil, papaverine, and phentolamine. The injection must be compounded by a pharmacy and administered via intracavernosal injection.[1][2][3] Trimix is typically compounded by a pharmacy in a sterile environment and then frozen. The compound is stable for up to 6 months while stored frozen and for 1 month if stored refrigerated beginning at the time of manufacture.[4]

References[edit]

  1. ^ R Seyam, K Mohamed, A Al Akhras and H Rashwan (2005). "A prospective randomized study to optimize the dosage of trimix ingredients and compare its efficacy and safety with prostaglandin E1". International Journal of Impotence Research: the Journal of Sexual Medicine 17 (4): 346–353. doi:10.1038/sj.ijir.3901313. PMID 15772683. 
  2. ^ S.C. Kim, I.H. Chang, H.J. Jeon (August 2003). "Preference for oral sildenafil or intracavernosal injection in patients with erectile dysfunction already using intracavernosal injection for > 1 year". BJU International 92 (3): 277–280. doi:10.1046/j.1464-410X.2003.04324.x. PMID 12887483. 
  3. ^ S. Israilov; Baniel, J; Shmueli, J; Niv, E; Engelstein, D; Segenreich, E; Livne, PM (2004). "Treatment program for erectile dysfunction in patients with cardiovascular diseases". The American Journal of Cardiology 93 (6): 689–693. doi:10.1016/j.amjcard.2003.11.049. PMID 15019870. 
  4. ^ Trissel Lawrence A, Zhang Yanping (May–June 2004). "Long-Term Stability of Trimix: A Three-Drug Injection Used to Treat Erectile Dysfunction". International Journal of Pharmaceutical Compounding: 231–235.