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Trihalomethanes (THMs) are chemical compounds in which three of the four hydrogen atoms of methane (CH4) are replaced by halogen atoms. Many trihalomethanes find uses in industry as solvents or refrigerants. THMs are also environmental pollutants, and many are considered carcinogenic. Trihalomethanes with all the same halogen atoms are called haloforms.
|IUPAC name||CAS registry number||Common name||Other names||Molecule|
|CHF3||trifluoromethane||75-46-7||fluoroform||Freon 23, R-23, HFC-23|
Trifluoromethane and chlorodifluoromethane are both used as refrigerants in some applications. Trihalomethanes released to the environment break down faster than chlorofluorocarbons (CFCs), thereby doing much less damage to the ozone layer . Chlorodifluoromethane is a refrigerant HCFC, or hydrochlorofluorocarbon, while fluoroform is an HFC, or hydrofluorocarbon. Fluoroform is not ozone depleting.
Unfortunately, the breakdown of trihalomethane HCFCs does still result in the creation of some free chlorine radicals in the upper atmosphere and subsequent ozone destruction. Ideally, HCFCs will be phased out entirely in favour of entirely nonchlorinated refrigerants.
Although still toxic and potentially carcinogenic, chloroform is significantly less harmful than carbon tetrachloride. Because of the health and regulatory issues associated with the use of carbon tetrachloride, in modern chemistry laboratories chloroform is used as a cheaper, cleaner alternative wherever possible.
Trihalomethanes are formed as a by-product predominantly when chlorine is used to disinfect water for drinking. They represent one group of chemicals generally referred to as disinfection by-products. They result from the reaction of chlorine or bromine with organic matter present in the water being treated. The THMs produced have been associated through epidemiological studies with some adverse health effects. Many governments set limits on the amount permissible in drinking water. However, trihalomethanes are only one group of many hundreds of possible disinfection by-products—the vast majority of which are not monitored—and it has not yet been clearly demonstrated which of these are the most plausible candidate for causation of these health effects. In the United States, the EPA limits the total concentration of the four chief constituents (chloroform, bromoform, bromodichloromethane, and dibromochloromethane), referred to as total trihalomethanes (TTHM), to 80 parts per billion in treated water.
Chloroform is also formed in swimming pools which are disinfected with chlorine or hypochlorite in the haloform reaction with organic substances (e.g. urine, sweat, hair and skin particles). Some of the THMs are quite volatile and may easily vaporize into the air. This makes it possible to inhale THMs while showering, for example. The EPA, however, has determined that this exposure is minimal compared to that from consumption. In swimmers, uptake of THMs is greatest via the skin with dermal absorption accounting for 80% of THM uptake. Exercising in a chlorinated pool increases the toxicity of a "safe" chlorinated pool atmosphere with toxic effects of chlorine byproducts greater in young swimmers than older swimmers. Studies in adolescents have shown an inverse relationship between serum testosterone levels and the amount of time spent in public pools. Chlorination by-products have been linked as a probable cause.