Toxicity category rating

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In 40 C.F.R. 156.62, the EPA established four Toxicity Categories for acute hazards of pesticide products, with "Category I" being the highest toxicity category. Most human hazard, precautionary statements, and human personal protective equipment statements are based upon the Toxicity Category of the pesticide product as sold or distributed. In addition, toxicity categories may be used for regulatory purposes other than labeling, such as classification for restricted use and requirements for child-resistant packaging.

In certain cases, statements based upon the Toxicity Category of the product as diluted for use are also permitted. A Toxicity Category is assigned for each of five types of acute exposure, as specified in the table below.


The four toxicity categories, from one to four are:

Acute toxicity categories for pesticide products[1][edit]

In the following table, the leftmost column lists the route of administration.

Oral LD50Up to and including 50 mg/kgFrom 50 to 500 mg/kgFrom 500 to 5000 mg/kgGreater than 5000 mg/kg
Inhalation LC50Up to and including 0.2 mg/LFrom 0.2 to 2 mg/LFrom 2. to 20 mg/LGreater than 20 mg/L
Dermal LD50Up to and including 200 mg/kgFrom 200 to 2000 mg/kgFrom 2000 to 20,000 mg/LGreater than 20,000 mg/kg
Eye EffectsCorrosive; corneal opacity not reversible within 7 daysCorneal opacity reversible within 7 days; irritation persisting for 7 daysNo corneal opacity; irritation reversible within 7 daysNo irritation.
Skin EffectsCorrosiveSevere irritation at 72 hoursModerate irritation at 72 hoursMild or slight irritation at 72 hours


  1. ^ "40 CFR 156.64: Toxicity Category". Code of Federal Regulations. Office of the Federal Register. Retrieved 2009-04-30.