This show was about the adventures of a talking tooth named Timmy and all his friends of Flossmore Valley as they go on adventures using their imaginations which would usually have Timmy thwarting bad guys like the Cavity Goon and Ms. Sweetie or the Gingivitis Gang.
Timmy the Tooth (performed by Kevin Carlson) - The main protagonist of the series. He is an adventurous tooth that lives with his best friend Brushbrush and is prone to burst into song.
Brushbrush (performed by Todd Mattox) - Timmy's pet toothbrush who acts like a dog. He whispers or "bristles" his words, although Timmy can understand him unlike the other characters. Brushbrush wears a collar and growls like an angry dog when provoked. He has the tendency to tickle Timmy often by licking his face.
Bubbles Gum (performed by Cheryl Blaylock) - Timmy's blue-colored friend is always ready to help Timmy as well as go on an adventure. She tends to take lead of things.
Ms. Flossie (performed by Michael Earl) - A cowgirl of sorts who is constantly having a good time. Despite her name, she has a blobishlike appearance.
Waxie - Flossie's unicorn hobby horse who is quite amusing....especially when she tries to eat the daisies.
Sidney Cyclops (performed by Bruce Lanoil) - A one-eyed male monster and Timmy's friend who wants to become the greatest paperboy in the world. He is very younger than Timmy and looks up to his best friend. He got to star in the episode "An Eye For a Tooth".
Annette Bruner Prower (performed by Christine Papelexis) - Timmy's orange-gold skinned friend is exactly a ditz, but always there for her friends. Her other name is also Full of Jello, her general middle and last names are Bruner and Prower.
Johnny Paste (performed by Allan Trautman) - A large, muscular, tube of toothpaste who is another one of Timmy's friends. He is well-meaning, but not all that bright.
Mr. Wisdom (performed by Phil Baron) - An old wisdom tooth who lives up on Wisdom Mountain. He gives advice to Timmy and his friends when they need it.
The Cavity Goon (performed by James Murray) - The main antagonist of the series. The Cavity Goon (otherwise known as Goonius Nemesis III) is a disgusting sight....a green creature covered with warts and a mouth full of decayed sharp teeth. He wears clothes that appear to be made of ripped-up leaves and is constantly bothering Timmy and his friends. In the episode "Lost My Brush," he even tried to kidnap Timmy by using the kidnapped Brushbrush to lure him in an attempt to turn him over to the Tooth Fairy for money.
Ms. Sweety (performed by Dina Fraboni) - The Cavity Goon's only sidekick. She is an enormous mint candy who always joins her boss on his evil plots.
The GingivitisGang - A group of creatures who are the secondary antagonists of the series. Much exactly evil like the Cavity Goon, and mean and plain bad. They spend most of their time looking for trouble and harassing Timmy and his friends. Despite antagonizing Timmy and his friends, the Gingivitis Gang would sometimes have to side with Timmy to stop the Cavity Goon (as seen in some episodes).
Leo (performed by Phil Baron) - The red-horned, lavender-haired, blue-skinned leader of the Gingivitis Gang.
Kay (performed by Bruce Lanoil) - The female bird-like member of the Gingivitis Gang with pumpkin skin and red hair.
Dee (performed by Dina Fraboni) - The blonde-haired, pinkish orange-skinned, female insect-like member of the Gingivitis Gang.
Darol (performed by James Murray) - The blue-haired, green-skinned member of the Gingivitis Gang.
Nolan (performed by Kevin Carlson) - The rose-colored, yellow-haired, hook-nosed, and green-horned member of the Gingivitis Gang.
Timmy in Space - When Timmy finds his old toy rocket, he imagines that he and Brushbrush are astronauts in space. Timmy and Brushbrush head to the planet Shmangy to liberate a space station from the Cavity Goon and Ms. Sweetie.
Operation Secret Birthday Surprise - Timmy prepares for his birthday party as his friends prepare a surprise for him in secret. Upon visiting Mr. Wisdom, Timmy is shown what Flossmore Valley would be like if Timmy wasn't around.
Molar Island - Timmy dreams that he and Brushbrush are taken to a dream vacation to Molar Island. Timmy ends up helping the locals when the ancient crown of King Cuspid has been stolen by the Gingivitis Tribe and the island will sink if the ancient crown of King Cuspid isn't returned to the hole it was placed over.
Malibu Timmy - Timmy and his friends go to the beach, but there's just one problem: Timmy can't swim! Timmy then imagines himself as a lifeguard where his friends are competing in a surfing competition against the Cavity Goon.
Lost My Brush - The Cavity Goon and Ms. Sweety plan to get rid of Brushbrush and Timmy by capturing Brushbrush as bait so that they can capture Timmy and hand him over to the Tooth Fairy.
Spooky Tooth - Timmy, Brushbrush, and Bubbles head to the desert and enter the Uncommon Pyramids where they help Mumfred the Mummy find his parents.
The Brush in the Stone - Timmy and Brushbrush get a case of the Itchy Polka Dots, so its up to Mr. Wisdom to read to Timmy a medieval story where Squire Timmy goes out on a dangerous and perilous journey to the Not-So-Sure-Its-A-Forest to grab some polka berries to make King Louis get cured from the Itchy Polka Dots.
An Eye for a Tooth - Sidney Cyclops can't be the greatest paper boy in the world if he can't see. So Timmy, Brushbrush, and Bubbles help Sidney to see in order for him to be the greatest paperboy in the world.
Rainy Day Adventure - During a rainy day, Timmy imagines that he is Captain Good Guy and Brushbrush is his first mate where they work to save Sunny the Sun from pirate versions of Cavity Goon and Ms. Sweetie.
Big Mouth Gulch - Timmy reads to his friends a western story where Sheriff Timmy deals with Goony the Kid and Ms. Sweetie when they come to Big Mouth Gulch.1996
Greg Ballora - Emmett, Lifeguard (episode 4), King Louie (episode 7), Thirstin the Cloud (episodes 4 and 9), Clem (eps. 9 & 10)
Phil Baron - Leo, Mr. Wisdom, Walter Crunelemuffin (episode 1), Sunny the Sun (episode 4), Raz the Beatnik (episode 5), Gus (episode 10)