Terazosin

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Terazosin
Systematic (IUPAC) name
(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
Clinical data
Trade namesHytrin
AHFS/Drugs.commonograph
MedlinePlusa693046
Legal status ?
Pharmacokinetic data
Protein binding90-94%
Half-life12 hours
Identifiers
CAS number63590-64-7 YesY
ATC codeG04CA03
PubChemCID 5401
DrugBankDB01162
ChemSpider5208 YesY
UNII8L5014XET7 YesY
KEGGD08569 YesY
ChEBICHEBI:9445 YesY
ChEMBLCHEMBL611 YesY
Synonyms[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone
Chemical data
FormulaC19H25N5O4 
Mol. mass387.433 g/mol
 YesY (what is this?)  (verify)
 
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Terazosin
Systematic (IUPAC) name
(RS)-6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine
Clinical data
Trade namesHytrin
AHFS/Drugs.commonograph
MedlinePlusa693046
Legal status ?
Pharmacokinetic data
Protein binding90-94%
Half-life12 hours
Identifiers
CAS number63590-64-7 YesY
ATC codeG04CA03
PubChemCID 5401
DrugBankDB01162
ChemSpider5208 YesY
UNII8L5014XET7 YesY
KEGGD08569 YesY
ChEBICHEBI:9445 YesY
ChEMBLCHEMBL611 YesY
Synonyms[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone
Chemical data
FormulaC19H25N5O4 
Mol. mass387.433 g/mol
 YesY (what is this?)  (verify)

Terazosin (marketed as Hytrin or Zayasel) is a selective alpha 1 antagonist used for treatment of symptoms of an enlarged prostate (BPH). It also acts to lower the blood pressure, and is therefore a drug of choice for men with hypertension and prostate enlargement.

It works by blocking the action of adrenaline on smooth muscle of the bladder and the blood vessel walls.

Most common side effects include dizziness, drowsiness, headache, constipation, loss of appetite, fatigue, nasal congestion or dry eyes, but they generally go away after only a few days of use. Therapy should always be started with a low dose to avoid first dose phenomenon.[1] Sexual side effects are rare, but may include priapism or erectile dysfunction.

References[edit]

  1. ^ Hytrin (Terazosin Hcl) drug warnings and precautions - prescription drugs and medications at RxList