Tenascin X

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Tenascin XB

PDB rendering based on 2cum.
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsTNXB; EDS3; HXBL; TENX; TN-X; TNX; TNXB1; TNXB2; TNXBS; XB; XBS
External IDsOMIM600985 MGI1932137 HomoloGene49589 GeneCards: TNXB Gene
Orthologs
SpeciesHumanMouse
Entrez714881877
EnsemblENSG00000168477ENSMUSG00000033327
UniProtP22105E9Q1J9
RefSeq (mRNA)NM_019105NM_031176
RefSeq (protein)NP_061978NP_112453
Location (UCSC)Chr 6:
32.01 – 32.08 Mb
Chr 17:
34.67 – 34.72 Mb
PubMed search[1][2]
 
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Tenascin XB

PDB rendering based on 2cum.
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsTNXB; EDS3; HXBL; TENX; TN-X; TNX; TNXB1; TNXB2; TNXBS; XB; XBS
External IDsOMIM600985 MGI1932137 HomoloGene49589 GeneCards: TNXB Gene
Orthologs
SpeciesHumanMouse
Entrez714881877
EnsemblENSG00000168477ENSMUSG00000033327
UniProtP22105E9Q1J9
RefSeq (mRNA)NM_019105NM_031176
RefSeq (protein)NP_061978NP_112453
Location (UCSC)Chr 6:
32.01 – 32.08 Mb
Chr 17:
34.67 – 34.72 Mb
PubMed search[1][2]

A member of the tenascin family, tenascin X (TN-X) also known as hexabrachion-like protein is a glycoprotein that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the TNXB gene.[1]

Gene[edit]

This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.[2]

Function[edit]

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing.[2]

Clinical significance[edit]

Deficiency causes one of the types of Ehlers-Danlos syndrome where collagen density is reduced and elastic fibers are fragmentated.[3]

References[edit]

  1. ^ Tee MK, Thomson AA, Bristow J, Miller WL (July 1995). "Sequences promoting the transcription of the human XA gene overlapping P450c21A correctly predict the presence of a novel, adrenal-specific, truncated form of tenascin-X". Genomics 28 (2): 171–8. doi:10.1006/geno.1995.1128. PMID 8530023. 
  2. ^ a b "Entrez Gene: tenascin XB". 
  3. ^ Zweers, MC; Schalkwijk, J; Van Kuppevelt, TH; Van Vlijmen-Willems, IM; Bergers, M; Lethias, C; Lamme, EN (2005). "Transplantation of reconstructed human skin on nude mice: a model system to study expression of human tenascin-X and elastic fiber components". Cell and tissue research 319 (2): 279–87. doi:10.1007/s00441-004-1011-6. PMID 15558324. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.