The name may be an Uyghur borrowing of the Arabictark, "to leave alone/out/behind, relinquish, abandon" + makan, "place". Another plausible explanation suggests it is derived from Turkitaqlar makan, describing "the place of ruins". Popular accounts claim that Takla Makan means "go in and you will never come out". It may also describe it as "The point of no return" or "The Desert of Death".[not in citation given (See discussion.)]
The Taklamakan Desert has an area of 337,000 km2 (130,116 sq. mi.), and includes the Tarim Basin, which is 1,000 kilometres (620 mi) long and 400 kilometres (250 mi) wide. It is crossed at its northern and at its southern edge by two branches of the Silk Road as travelers sought to avoid the arid wasteland. It is the world's second largest shifting sand desert with about 85% made up of shifting sand dunes ranking 18th in size in a ranking of the world's largest non-polar deserts.
In recent years, the People's Republic of China has constructed a cross-desert highway that links the cities of Hotan (on the southern edge) and Luntai (on the northern edge). In recent years, the desert has expanded in some areas, its sands enveloping farms and villages as a result of desertification.
Because it lies in the rain shadow of the Himalayas,Taklamakan is a paradigmatic cold desert climate. Given its relative proximity with the cold to frigid air masses in Siberia, extreme lows are recorded in wintertime, sometimes well below −20 °C (−4 °F). During the 2008 Chinese winter storms episode, the Taklamakan was reported to be covered for the first time in its entirety with a thin layer of snow reaching 4 centimetres (1.6 in), with a temperature of −26.1 °C (−15 °F) in some observatories.
Its extreme inland position, virtually in the very heartland of Asia and thousands of kilometres from any open body of water, accounts for the cold character of its nights even during summertime.
The Molcha (Moleqie) River forms a vast alluvial fan at the southern border of the Taklamakan Desert, as it leaves the Altyn-Tagh mountains and enters the desert in the western part of the Qiemo County. The left side appears blue from water flowing in many streams. The picture is taken in May, when the river is full with the snow/glacier meltwater. 
There is very little water in the desert and it is hazardous to cross. Merchant caravans on the Silk Road would stop for relief at the thriving oasis towns. It was in close proximity to many of the ancient civilizations - to the Northwest is the Amu Darya basin, to the Southwest the Afghanistan mountain passes lead to Iran and India, to the East is China, and even to the North can be found ancient towns like Almaty.
Later, the Taklamakan was inhabited by Turkic peoples. Starting with the Tang Dynasty, the Chinese periodically extended their control to the oasis cities of the Taklamakan in order to control the important silk route trade across Central Asia. Periods of Chinese rule were interspersed with rule by Turkic, Mongol and Tibetan peoples. The present population consists largely of Turkic Uyghur people.