Cycloastragenol

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Cycloastragenol
Identifiers
CAS number84605-18-5 YesY
PubChem44144539
ChemSpider10252332
Jmol-3D imagesImage 1
Properties
Molecular formulaC30H50O5
Molar mass490.72 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references
 
  (Redirected from TA-65)
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Cycloastragenol
Identifiers
CAS number84605-18-5 YesY
PubChem44144539
ChemSpider10252332
Jmol-3D imagesImage 1
Properties
Molecular formulaC30H50O5
Molar mass490.72 g/mol
 YesY (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Cycloastragenol has been shown to activate telomerase in a 2009 study by [1] Scientist Hector F. Valenzuela. Recently RevGenetics released their conclusions on TA-65 that showed it is the single molecule used in TA-65 [2]

Another study [3] showed that TA-65 intake improved health span (not lifespan), however the researchers did not investigate the extension of lifespan in the studied laboratory mice as this was not the focus of the project (it was associated aging diseases). Although the first study was done in 2005 for supplement based telomerase activators, In the 8 years since the first study, there has been no study done that shows a telomerase activator taken as a supplement has extended lifespan.

Many products exist that contain cycloastragenol such as CT-95, CounterAgingWise, Smartcity, and Jeunesse. These products do not claim patent or telomerase benefits of any kind but only assure to provide the pure cycloastragenol ingredient described in this article.

The most advertised product that contains Cycloastragenol is TA-65MD as it is the only company licensed to make patent claims by Geron for the Cycloastragenol ingredient.[4] TA-65MD is the registered trade name for the telomerase activator derived from an Astragalus plant such as A. propinquus.

The active ingredient is produced under GMP in the United States by Telomerase Activation Sciences, Inc. (T.A. Sciences).[5] The active ingredient is a patented, naturally occurring, molecule encapsulated in a polymer that has been available on the market since 2005. Its method of action is to activate the hTERT gene, thereby activating the enzyme telomerase. The Cycloastragenol compound was originally discovered by Geron Corporation and licensed to T.A. Sciences. Dr. Bill Andrews of Sierra Sciences has done extensive testing on the anti-aging aspect of TA-65.[6]

Extensive toxicity testing has shown it to be safe for human consumption. In a recent peer-reviewed study published by the low impact factor journal Rejuvenation Research, TA-65 was shown to improve biological markers associated with human health span through the lengthening of short telomeres and rescuing of old cells, although the significance of these findings in actual life expectancy is unknown.[7] Publications in high-impact peer-reviewed journals are lacking however, and much of the online documentation supporting its use is sponsored by its manufacturers.

As part of a study sponsored by its manufacturer, TA-65 was tested by UCLA scientist Rita B. Effros and UCLA Visiting Scholar and RevGenetics[8] Scientist Hector F. Valenzuela. The small study (6 participants) found that TA-65 activated telomerase in all samples of subjects tested, while another telomerase activator did not.[9]

The manufacturer of TA-65 carried out a User Survey from October 2012 to February 2013. More than 80% of those returning the survey self-reported improvements in: Immune function, Mood and Sense of General Well-Being, Quality of their hair. 75% of those studied experienced improved joint mobility and skin quality, a reduction in joint pain and colds, improved energy and greater exercise tolerance and endurance. 50% of those studied saw improvements in sleep quality, vision, and sexual function.[10] As disordered telomerase function is a feature of almost all cancers,[11] there is an unknown, but theoretical risk of oncogene-mediated cancer promotion through the use of telomerase activators.

TA-65 was mentioned in the BBC documentary, Don't Grow Old.

References[edit]

  1. ^ http://www.jimmunol.org/cgi/content/meeting_abstract/182/1_MeetingAbstracts/90.30
  2. ^ http://www.cycloastragenol.com/TA-65-is-Cycloastragolx.pdf
  3. ^ http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/full
  4. ^ http://www.cycloastragenol.com/RevGenetics-Letter-About-TA65-Cycloastragenol-2013x.pdf
  5. ^ TA Sciences
  6. ^ Dr. Bill Andrews anti-aging test of TA-65
  7. ^ Harley, Calvin B; Liu, Weimin; Blasco, Maria; Vera, Elsa; Andrews, William H; Briggs, Laura A; Raffaele, Joseph M (1 February 2011). "A Natural Product Telomerase Activator As Part of a Health Maintenance Program". Rejuvenation Research 14 (1): 45–56. doi:10.1089/rej.2010.1085. PMC 3045570. PMID 20822369. Retrieved 19 April 2012. 
  8. ^ TA-65
  9. ^ Valenzuela, Hector F; Effros, Rita B; Dimler, Taylor; Sweeney, Greg; Bateman, RileyH; Malgora, Brenda (14 January 2013). "Functional Assessment of Pharmacological Telomerase Activators in Human T Cells". Cells: 57–66. doi:10.3390/cells2010057. 
  10. ^ TA-65 Users Survey
  11. ^ Shay, JW; Wright, WE (1 January 2001). "Telomeres and telomerase: implications for cancer and aging". Radiation Research 155 (1 pt 2): 188–193. PMID 11121233.