Cycloastragenol

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Cycloastragenol
Cycloastragenol.svg
Identifiers
CAS number84605-18-5 YesY
PubChem44144539
ChemSpider10252332 N
Jmol-3D imagesImage 1
Properties
Molecular formulaC30H50O5
Molar mass490.72 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references
 
  (Redirected from TA-65)
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Cycloastragenol
Cycloastragenol.svg
Identifiers
CAS number84605-18-5 YesY
PubChem44144539
ChemSpider10252332 N
Jmol-3D imagesImage 1
Properties
Molecular formulaC30H50O5
Molar mass490.72 g/mol
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

Cycloastragenol is a molecule isolated from various species of Astragalus that is purported to have telomerase activation activity. A single in vitro study done in 2009 led to claims that cycloastragenol may activate telomerase, leading to controversial claims for its role in reducing the effects of aging.[1] Scientist Hector F. Valenzuela.

In late 2013, RevGenetics released their conclusions on TA-65 that showed it is the single molecule Cycloastragenol [2] used in TA-65.[3] More recently, on May 15, 2014 RevGenetics released a press release where they provide new information about a public UK government application where TA Sciences state (among other things) that the active ingredient in TA-65 is Cycloastragenol.[4]

Another study [5] showed that a composition of Cycloastragenol (The active ingredient in TA-65 according to the newly released UK application)[6]) intake improved health span (not lifespan), however the researchers did not investigate the extension of lifespan in the studied laboratory mice as this was not the focus of the project (it was associated aging diseases). Although the first TA Sciences study was done in 2005 for supplement based telomerase activators, In the 8 years since the first study, there has been no study done that shows a telomerase activator taken as a supplement has extended lifespan.

Many products that contain cycloastragenol are marketed as health supplements, including Cycloastragenol DR,[7] HTA98,[8] Stem Cell 100[9] and TA-65MD.[10]

Cycloastragenol is a natural ingredient extracted in minute quantities from the root of the astrgalus plant which has been known about in China for thousands of years. It is not a proprietary ingredient.

Its method of action is to activate the hTERT gene, thereby activating the enzyme telomerase. The Cycloastragenol compound was researched by Geron Corporation and licensed to T.A. Sciences. Dr. Bill Andrews of Sierra Sciences has done testing on the anti-aging aspect of TA-65.,[11] however quality trials on the benefits of the product are lacking, and there are no high impact journal articles reviewing the efficacy of the TA65-MD, or indeed cyclostragenol.

Toxicity testing has shown it to be safe for human consumption. In a recent peer-reviewed study published by the low impact factor journal Rejuvenation Research, TA-65 was shown to improve biological markers associated with human health span through the lengthening of short telomeres and rescuing of old cells, although the significance of these findings in actual life expectancy is unknown.[12] Publications in high-impact peer-reviewed journals are lacking however, and much of the online documentation supporting its use is sponsored by its manufacturers.

As part of a study sponsored by RevGenetics, the Cycloastragenol based product TA-65 was tested by UCLA scientist Rita B. Effros and UCLA Visiting Scholar and RevGenetics[13] Scientist Hector F. Valenzuela. The small study (6 participants) found that TA-65 activated telomerase in all samples of subjects tested, while another telomerase activator did not.[14] The clinical significance of this work is uncertain.

The manufacturer of Cycloastragenol based product TA-65 carried out a User Survey (self-reporting) from October 2012 to February 2013. Although a self-selected, self-reported study is of dubious reliability, this questionnaire reported that more than 80% of those returning the survey self-reported improvements in immune function, mood, and aense of general well-being, and quality of their hair. 75% of those studied reported improved joint mobility and skin quality, a reduction in joint pain and colds, improved energy and greater exercise tolerance and endurance. 50% of those studied saw improvements in sleep quality, vision, and sexual function.[15] As disordered telomerase function is a feature of almost all cancers,[16] there is an unknown, but theoretical risk of oncogene-mediated cancer promotion through the use of telomerase activators.

TA-65 was mentioned in the BBC documentary, Don't Grow Old.

References[edit]

  1. ^ http://www.jimmunol.org/cgi/content/meeting_abstract/182/1_MeetingAbstracts/90.30
  2. ^ http://www.cycloastragenol.com
  3. ^ http://www.cycloastragenol.com/TA-65-is-Cycloastragolx.pdf
  4. ^ http://www.prweb.com/releases/ta-65/cycloastragenol/prweb11854738.htm
  5. ^ http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2011.00700.x/full
  6. ^ http://www.prweb.com/releases/ta-65/cycloastragenol/prweb11854738.htm
  7. ^ http://www.revgenetics.com/store/p-124-cycloastragenol-drbrstomach-acid-protected-cycloastragenol.aspx
  8. ^ http://www.HTA98.com
  9. ^ http://www.cycloastragenol.com/Intertek-Stem-Cell-100-12182013-Cyclo.pdf
  10. ^ http://www.cycloastragenol.com/TA-65-is-Cycloastragolx.pdf
  11. ^ Dr. Bill Andrews anti-aging test of TA-65
  12. ^ Harley, Calvin B; Liu, Weimin; Blasco, Maria; Vera, Elsa; Andrews, William H; Briggs, Laura A; Raffaele, Joseph M (1 February 2011). "A Natural Product Telomerase Activator As Part of a Health Maintenance Program". Rejuvenation Research 14 (1): 45–56. doi:10.1089/rej.2010.1085. PMC 3045570. PMID 20822369. Retrieved 19 April 2012. 
  13. ^ TA-65
  14. ^ Valenzuela, Hector F; Effros, Rita B; Dimler, Taylor; Sweeney, Greg; Bateman, RileyH; Malgora, Brenda (14 January 2013). "Functional Assessment of Pharmacological Telomerase Activators in Human T Cells". Cells: 57–66. doi:10.3390/cells2010057. 
  15. ^ TA-65 Users Survey
  16. ^ Shay, JW; Wright, WE (1 January 2001). "Telomeres and telomerase: implications for cancer and aging". Radiation Research 155 (1 pt 2): 188–193. doi:10.1667/0033-7587(2001)155[0188:tatifc]2.0.co;2. PMID 11121233.