From Wikipedia, the free encyclopedia - View original article
|It has been suggested that Rectal (medicine) be merged into this article. (Discuss) Proposed since December 2013.|
|This article needs additional citations for verification. (January 2013)|
A suppository is a drug delivery system that is inserted into the rectum (rectal suppository), vagina (vaginal suppository) or urethra (urethral suppository), where it dissolves or melts and is absorbed into the blood stream. They are used to deliver both systemically and locally acting medications.
Rectal suppositories are commonly used for:
In 1991, Abd-El-Maeboud and his colleagues published a study on suppository insertion in The Lancet, explaining that the "torpedo" shape, when introduced to the patient blunt end first, helps the device to travel internally, increasing its efficacy. The findings of this single study have been challenged as insufficient evidence on which to base clinical practice.
Non-laxative rectal suppositories are to be used after defecation, so as not to be expelled before they are fully dissolved and the substance is absorbed. The use of an examination glove or a finger cot can ease insertion by protecting the rectal wall from fingernail(s).
Vaginal suppositories are meant for introduction into the vagina. These are generally conical, rod shaped or wedge shaped and are larger than Rectal suppositories (4-8 g). Commonly used for local actions in the treatment of gynecological ailments, including vaginal infections such as candidiasis.
Alprostadil pellets are urethral suppositories used for the treatment of severe erectile dysfunction. They are marketed under the name Muse in the United States. Its use has diminished since the development of oral impotence medications.
Some suppositories are made from a greasy base, such as cocoa butter, in which the active ingredient and other excipients are dissolved; this grease will melt at body temperature (this may be a source of discomfort for the patient, as the melted grease may pass through the anus during flatus). Other suppositories are made from a water soluble base, such as polyethylene glycol. Suppositories made from polyethylene glycol are commonly used in vaginal and urethral suppositories. Glycerin suppositories are made of glycerol and gelatin.
Suppositories may also be used when a patient has a vomiting tendency, as oral medication can be vomited out.
Liquid suppository involves injecting a liquid, typically a laxative, with a small syringe, into the rectum.
|Wikimedia Commons has media related to:|