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In statistics, **statistical significance** (or **statistically significant result**) is attained when a *p*-value is less than the significance level.^{[1]}^{[2]}^{[3]}^{[4]}^{[5]}^{[6]}^{[7]} The *p*-value is the probability of observing an effect given that the null hypothesis is true whereas the significance or alpha (α) level is the probability of rejecting the null hypothesis given that it is true (type I error).^{[8]} As a matter of logic, the significance level is always set ahead of time, usually at a threshold value of 0.05 (5%).^{[9]} Other alpha values (e.g., 0.01) are also used, depending on the field of study.

Statistical significance is fundamental to statistical hypothesis testing as it allows investigators to reject null hypotheses.^{[10]}^{[11]} In any experiment or observation that involves drawing a sample from a population, there is always the possibility that an observed effect would have occurred due to sampling error alone.^{[12]}^{[13]} But if the *p*-value is less than the significance level (e.g., *p* < 0.05), then an investigator can conclude that the observed effect actually reflects the characteristics of the population rather than just sampling error.^{[10]} An investigator may then report that the result attains statistical significance, thereby rejecting the null hypothesis.^{[14]}

The present-day concept of statistical significance originated with Ronald Fisher when he developed statistical hypothesis testing based on *p*-values in the early 20th century.^{[2]}^{[15]}^{[16]} It was Jerzy Neyman and Egon Pearson who later recommended that the significance level be set ahead of time, prior to any data collection.^{[17]}^{[18]}

Statistical significance is not the same as research, theoretical, or practical significance.^{[10]}^{[11]}^{[19]}

Main article: History of statistics

The concept of statistical significance was originated by Ronald Fisher when he developed statistical hypothesis testing, which he described as "tests of significance", in his 1925 publication, *Statistical Methods for Research Workers*.^{[2]}^{[15]}^{[16]} Fisher suggested a probability of one in twenty (0.05) as a convenient cutoff level to reject the null hypothesis.^{[17]} In their 1933 paper, Jerzy Neyman and Egon Pearson recommended that the significance level (e.g. 0.05), which they called α, be set ahead of time, prior to any data collection.^{[17]}^{[18]}

Despite his initial suggestion of 0.05 as a significance level, Fisher did not intend this cutoff value to be fixed, and in his 1956 publication *Statistical methods and scientific inference* he recommended that significant levels be set according to specific circumstances.^{[17]}

Main articles: Statistical hypothesis testing, Null hypothesis, p-value and Type I and type II errors

Statistical significance plays a pivotal role in statistical hypothesis testing, where it is used to determine if a null hypothesis should be rejected or retained. A null hypothesis is the general or default statement that nothing happened or changed.^{[20]} For a null hypothesis to be rejected as false, the result has to be identified as being statistically significant, i.e. unlikely to have occurred due to sampling error alone.

To determine if a result is statistically significant, a researcher would have to calculate a *p*-value, which is the probability of observing an effect given that the null hypothesis is true.^{[7]} The null hypothesis is rejected if the *p*-value is less than the significance or α level. The α level is the probability of rejecting the null hypothesis given that it is true (type I error) and is most often set at 0.05 (5%). If the α level is 0.05, then the conditional probability of a type I error, *given that the null hypothesis is true*, is 5%.^{[21]} Then a statistically significant result is one in which the observed *p*-value is less than 5%, which is formally written as *p* < 0.05.^{[21]}

If an observed *p*-value is not lower than the significance level, then rather than simply accepting the null hypothesis, where feasible it would often be appropriate to increase the sample size of the study, and see if the significance level is reached.^{[22]}

If the α level is set at 0.05, it means that the rejection region comprises 5% of the sampling distribution.^{[23]} This 5% can be allocated to one side of the sampling distribution as in a one-tailed test or partitioned to both sides of the distribution as in a two-tailed test, with each tail (or rejection region) containing 2.5% of the distribution. One-tailed tests are more powerful than two-tailed tests, as a null hypothesis can be rejected with a less extreme result.

Main articles: Standard deviation and Normal distribution

In specific fields such as particle physics and manufacturing, statistical significance is often expressed in multiples of the standard deviation or sigma (σ) of a normal distribution, with significance thresholds set at a much stricter level (e.g. 5σ).^{[24]}^{[25]} For instance, the certainty of the Higgs boson particle's existence was based on the 5σ criterion, which corresponds to a *p*-value of about 1 in 3.5 million.^{[25]}^{[26]}

Main article: Effect size

Researchers focusing solely on whether their results are statistically significant might report findings that are not necessarily substantive.^{[27]} To gauge the research significance of their result, researchers are also encouraged to report the effect size along with *p*-values (in cases where the effect being tested for is defined in terms of an effect size): the effect size quantifies the strength of an effect, such as the distance between two means or the correlation between two variables.^{[28]}

- A/B testing
- ABX test
- Confidence level, the complement of the significance level
- Effect size
- Fisher's method for combining independent tests of significance
- Look-elsewhere effect
- Texas sharpshooter fallacy (gives examples of tests where the significance level was set too high)
- Reasonable doubt
- Statistical hypothesis testing

**^**Redmond, Carol; Colton, Theodore (2001). "Clinical significance versus statistical significance".*Biostatistics in Clinical Trials*. Wiley Reference Series in Biostatistics (3rd ed.). West Sussex, United Kingdom: John Wiley & Sons Ltd. pp. 35–36. ISBN 0-471-82211-6.- ^
^{a}^{b}^{c}Cumming, Geoff (2012).*Understanding The New Statistics: Effect Sizes, Confidence Intervals, and Meta-Analysis*. New York, USA: Routledge. pp. 27–28. **^**Krzywinski, Martin; Altman, Naomi (30 October 2013). "Points of significance: Significance, P values and t-tests".*Nature Methods*(Nature Publishing Group)**10**(11): 1041–1042. doi:10.1038/nmeth.2698. Retrieved 3 July 2014.**^**Sham, Pak C.; Purcell, Shaun M (17 April 2014). "Statistical power and significance testing in large-scale genetic studies".*Nature Reviews Genetics*(Nature Publishing Group)**15**(5): 335–346. doi:10.1038/nrg3706. Retrieved 3 July 2014.**^**Johnson, Valen E. (October 9, 2013). "Revised standards for statistical evidence".*Proceedings of the National Academy of Sciences*(National Academies of Science). doi:10.1073/pnas.1313476110. Retrieved 3 July 2014.**^**Altman, Douglas G. (1999).*Practical Statistics for Medical Research*. New York, USA: Chapman & Hall/CRC. p. 167. ISBN 978-0412276309.- ^
^{a}^{b}Devore, Jay L. (2011).*Probability and Statistics for Engineering and the Sciences*(8th ed.). Boston, MA: Cengage Learning. pp. 300–344. ISBN 0-538-73352-7. **^**Schlotzhauer, Sandra (2007).*Elementary Statistics Using JMP (SAS Press)*(PAP/CDR ed.). Cary, NC: SAS Institute. pp. 166–169. ISBN 1-599-94375-1.**^**Craparo, Robert M. (2007). "Significance level". In Salkind, Neil J.*Encyclopedia of Measurement and Statistics***3**. Thousand Oaks, CA: SAGE Publications. pp. 889–891. ISBN 1-412-91611-9.- ^
^{a}^{b}^{c}Sirkin, R. Mark (2005). "Two-sample t tests".*Statistics for the Social Sciences*(3rd ed.). Thousand Oaks, CA: SAGE Publications, Inc. pp. 271–316. ISBN 1-412-90546-X. - ^
^{a}^{b}Borror, Connie M. (2009). "Statistical decision making".*The Certified Quality Engineer Handbook*(3rd ed.). Milwaukee, WI: ASQ Quality Press. pp. 418–472. ISBN 0-873-89745-5. **^**Babbie, Earl R. (2013). "The logic of sampling".*The Practice of Social Research*(13th ed.). Belmont, CA: Cengage Learning. pp. 185–226. ISBN 1-133-04979-6.**^**Faherty, Vincent (2008). "Probability and statistical significance".*Compassionate Statistics: Applied Quantitative Analysis for Social Services (With exercises and instructions in SPSS)*(1st ed.). Thousand Oaks, CA: SAGE Publications, Inc. pp. 127–138. ISBN 1-412-93982-8.**^**McKillup, Steve (2006). "Probability helps you make a decision about your results".*Statistics Explained: An Introductory Guide for Life Scientists*(1st ed.). Cambridge, United Kingdom: Cambridge University Press. pp. 44–56. ISBN 0-521-54316-9.- ^
^{a}^{b}Poletiek, Fenna H. (2001). "Formal theories of testing".*Hypothesis-testing Behaviour*. Essays in Cognitive Psychology (1st ed.). East Sussex, United Kingdom: Psychology Press. pp. 29–48. ISBN 1-841-69159-3. - ^
^{a}^{b}Fisher, Ronald A. (1925).*Statistical Methods for Research Workers*. Edinburgh, UK: Oliver and Boyd. p. 43. ISBN 0-050-02170-2. - ^
^{a}^{b}^{c}^{d}Quinn, Geoffrey R.; Keough, Michael J. (2002).*Experimental Design and Data Analysis for Biologists*(1st ed.). Cambridge, UK: Cambridge University Press. pp. 46–69. ISBN 0-521-00976-6. - ^
^{a}^{b}Neyman, J.; Pearson, E.S. (1933). "The testing of statistical hypotheses in relation to probabilities a priori".*Mathematical Proceedings of the Cambridge Philosophical Society***29**: 492–510. doi:10.1017/S030500410001152X. **^**Myers, Jerome L.; Well, Arnold D.; Lorch Jr, Robert F. (2010). "The t distribution and its applications".*Research Design and Statistical Analysis: Third Edition*(3rd ed.). New York, NY: Routledge. pp. 124–153. ISBN 0-805-86431-8.**^**Meier, Kenneth J.; Brudney, Jeffrey L.; Bohte, John (2011).*Applied Statistics for Public and Nonprofit Administration*(3rd ed.). Boston, MA: Cengage Learning. pp. 189–209. ISBN 1-111-34280-6.- ^
^{a}^{b}Healy, Joseph F. (2009).*The Essentials of Statistics: A Tool for Social Research*(2nd ed.). Belmont, CA: Cengage Learning. pp. 177–205. ISBN 0-495-60143-8. **^**Cohen, Barry H. (2008).*Explaining Psychological Statistics*(3rd ed.). Hoboken, NJ: John Wiley and Sons. pp. 46–83. ISBN 0-470-00718-4.**^**Health, David (1995).*An Introduction To Experimental Design And Statistics For Biology*(1st ed.). Boston, MA: CRC press. pp. 123–154. ISBN 1-857-28132-2.**^**Vaughan, Simon (2013).*Scientific Inference: Learning from Data*(1st ed.). Cambridge, UK: Cambridge University Press. pp. 146–152. ISBN 1-107-02482-X.- ^
^{a}^{b}Bracken, Michael B. (2013).*Risk, Chance, and Causation: Investigating the Origins and Treatment of Disease*(1st ed.). New Haven, CT: Yale University Press. pp. 260–276. ISBN 0-300-18884-6. **^**Franklin, Allan (2013). "Prologue: The rise of the sigmas".*Shifting Standards: Experiments in Particle Physics in the Twentieth Century*(1st ed.). Pittsburgh, PA: University of Pittsburgh Press. pp. Ii–Iii. ISBN 0-822-94430-8.**^**Carver, Ronald P. (1978). "The Case Against Statistical Significance Testing".*Harvard Educational Review***48**: 378–399.**^**Pedhazur, Elazar J.; Schmelkin, Liora P. (1991).*Measurement, Design, and Analysis: An Integrated Approach*(Student ed.). New York, NY: Psychology Press. pp. 180–210. ISBN 0-805-81063-3.

- Ziliak, Stephen, and McCloskey, Deirdre, (2008).
*The Cult of Statistical Significance: How the Standard Error Costs Us Jobs, Justice, and Lives*. Ann Arbor, University of Michigan Press, 2009. - Thompson, Bruce, (2004). The "significance" crisis in psychology and education.
*Journal of Socio-Economics*, 33, pp. 607–613. - Chow, Siu L., (1996).
*Statistical Significance: Rationale, Validity and Utility,*Volume 1 of series*Introducing Statistical Methods,*Sage Publications Ltd, ISBN 978-0-7619-5205-3 – argues that statistical significance is useful in certain circumstances.

- Kline, Rex, (2004).
*Beyond Significance Testing: Reforming Data Analysis Methods in Behavioral Research*Washington, DC: American Psychological Association.

Wikiversity has learning materials about Statistical significance |

- The article "Earliest Known Uses of Some of the Words of Mathematics (S)" contains an entry on Significance that provides some historical information.
- "The Concept of Statistical Significance Testing" (February 1994): article by Bruce Thompon hosted by the ERIC Clearinghouse on Assessment and Evaluation, Washington, D.C.
- "What does it mean for a result to be "statistically significant"?" (no date): an article from the Statistical Assessment Service at George Mason University, Washington, D.C.