From Wikipedia, the free encyclopedia - View original article

Jump to: navigation, search

Spondyloarthropathy is any joint disease of the vertebral column.[1] Spondyloarthropathy with inflammation is called spondylarthritis. In contrast, spondylopathy is a disease of the vertebra itself, but many conditions involve both spondylopathy and spondyloarthropathy. In the broadest sense, the term spondyloarthropathy includes joint involvement of vertebral column from any type of joint disease, including rheumatoid arthritis and osteoarthritis, but the term is often used for a specific group of disorders with certain common features, the group often being termed specifically seronegative spondylarthropathies. They have an increased incidence of HLA-B27, as well as negative rheumatoid factor and ANA. Enthesopathy is also sometimes present in association with seronegative spondarthritides. Nonvertebral symptoms of spondyloarthropathies include asymmetic peripheral arthritis (which is distinct from rheumatoid arthritis), arthritis of the Toe IP Joints, sausage digits, achilles tenosynovitis, plantar fasciitis, costochondritis, iritis, and mucocutaneous lesions. However, lower back pain is the most common clinical presentation of the disease; this back pain is unique because it decreases with activity.


Seronegative spondyloarthropathy

Seronegative spondyloarthropathy (or seronegative spondyloarthritis) is a group of diseases involving the axial skeleton[2] and having a negative serostatus.

"Seronegative" refers to the fact that these diseases are negative for rheumatoid factor,[3] indicating a different pathophysiological mechanism of disease than what is commonly seen in rheumatoid arthritis.


The following conditions in the table are typically included within the group of seronegative spondylarthropathies:

ConditionPercent of people with the
condition who are HLA-B27 positive
Ankylosing Spondylitis[4][5]
  • Caucasians: 92%[6]
  • African-Americans:50%
Reactive arthritis[4][5] (Reiter's syndrome)60-80%
enteropathic spondylitis or spondylitis associated with

inflammatory bowel disease[4][5] (including Crohn's disease and ulcerative colitis)

Psoriatic arthritis[4][5]60%
Isolated acute anterior uveitis50%
Undifferentiated spondyloarthropathy[4][5] (USpA)20-25%

Some sources also include Behcet's disease[citation needed] and Whipple's disease.[7]

Common characteristics

These diseases have the following conditions in common:


  1. ^ thefreedictionary.com/spondyloarthropathy citing:
    • Mosby's Medical Dictionary, 8th edition. © 2009
    • Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003
    • Saunders Comprehensive Veterinary Dictionary, 3 ed. © 2007
  2. ^ Howe HS, Zhao L, Song YW, et al. (February 2007). "Seronegative spondyloarthropathy--studies from the Asia Pacific region". Ann. Acad. Med. Singap. 36 (2): 135–41. PMID 17364081. http://www.annals.edu.sg/pdf/36VolNo2Feb2007/V36N2p135.pdf. 
  3. ^ "Seronegative Spondyloarthropathies: Joint Disorders: Merck Manual Professional". http://www.merck.com/mmpe/sec04/ch034/ch034d.html. Retrieved 2008-12-15. 
  4. ^ a b c d e Luong AA, Salonen DC (August 2000). "Imaging of the seronegative spondyloarthropathies". Curr Rheumatol Rep 2 (4): 288–96. doi:10.1007/s11926-000-0065-z. PMID 11123073. 
  5. ^ a b c d e f g h i j k Elizabeth D Agabegi; Agabegi, Steven S. (2008). Step-Up to Medicine (Step-Up Series). Hagerstwon, MD: Lippincott Williams & Wilkins. ISBN 0-7817-7153-6. 
  6. ^ Ankylosing Spondylitis and Undifferentiated Spondyloarthropathy Workup Author: Lawrence H Brent. Chief Editor: Herbert S Diamond. Updated: Apr 19, 2011
  7. ^ Várvölgyi C, Bubán T, Szakáll S, et al. (April 2002). "Fever of unknown origin with seronegative spondyloarthropathy: an atypical manifestation of Whipple's disease". Ann. Rheum. Dis. 61 (4): 377–8. doi:10.1136/ard.61.4.377. PMC 1754069. PMID 11874851. //www.ncbi.nlm.nih.gov/pmc/articles/PMC1754069/. 
  8. ^ Shankarkumar U, Devraj JP, Ghosh K, Mohanty D (2002). "Seronegative spondarthritis and human leucocyte antigen association". Br. J. Biomed. Sci. 59 (1): 38–41. PMID 12000185. 
  9. ^ Maria Antonietta D'Agostino, MD, Ignazio Olivieri, MD. (June 2006). Enthesitis. Clinical Rheumatology. pp. 473–486. doi:10.1016/j.berh.2006.03.007. 
  10. ^ The Free Dictionary (2009). "Enthesitis". http://medical-dictionary.thefreedictionary.com/enthesitis. Retrieved 2010-11-27. 

External links