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Southwest Florida is the region along the south west gulf coast of the U.S. State of Florida. Definitions of the region vary, though its boundaries are generally considered to put it south of the Tampa Bay area, west of Lake Okeechobee, and mostly north of the Everglades and to include Manatee, Sarasota, Charlotte, Lee, and Collier counties. For some purposes, the inland counties of DeSoto, Glades, and Hendry, and the thinly populated mainland section Monroe County, south of Collier, are also included.
The region includes the North Port-Bradenton-Sarasota Metropolitan Statistical Area (sometimes alternately considered a part of the Tampa Bay Area to the north), the Punta Gorda Metropolitan Statistical Area, the Cape Coral-Fort Myers Metropolitan Statistical Area, and the Naples-Marco Island Metropolitan Statistical Area. The most populous county in the region is Lee County, and the region's largest city is Cape Coral with a population of 154,305 as of 2010.
Southwest Florida was largely ignored by commercial developers until the late 1800s, and as such, lacks much of the heavier development present in other parts of Florida, such as that found in the central or southern regions of the state. In recent years however, there has been a major real estate boom focusing on downtown Fort Myers (high-rise residential condominiums); southern Lee County (commercial development and high-technology); eastern Collier County (residential development); and eastern parts of Bradenton
Overall, the region notably suffers from urban sprawl; however, numerous efforts in recent years have been made to remedy this situation, especially as the urbanized area of the coastal counties pushes eastward into agricultural land and the sensitive Everglades.
Inland counties (DeSoto, Hendry and Glades Counties) are notably rural, with the primary economic driver being agriculture. Important products grown in this area include tomatoes, beef, sugarcane, and citrus products including oranges. Agricultural harvesting in Southwest Florida employs approximately 16,000 seasonal workers, 90 percent of which are thought to be migrants. 
Each county in the region has its own county government. Within each county, there are also self-governing cities, towns and villages. The remaining majority of land in each county is controlled directly by the county government. It is also very common for incorporated municipalities to contract county services in order to save costs and avoid redundancy. The region is designated as one of Florida's 4 districts for the Committee of Southern Historic Preservation (C-SHP). The district has been represented by Tommy Stolly since 2013.
Southwest Florida is served by several major highways, including the Tamiami Trail (U.S. 41) and the Interstate 75 freeway, both of which connect the area to Tampa to the north, and Greater Miami–Ft. Lauderdale to the east. Long-term cooperative infrastructure planning is coordinated by the Southwest Florida Regional Planning Council (web site), and in heavily populated Lee County, the Metropolitan Planning Organization.
Southwest Florida International Airport, located in South Fort Myers, served over 7.42 million passengers in 2009  and offers non-stop flights to 3 cities in Europe and 2 in Canada, in addition to 36 domestic airports. The area's secondary airport, Sarasota-Bradenton International Airport, served 1.34 million passengers in 2009.
The Port of Manatee provides a full range of port services for commercial, industrial and cruise ship purposes.
Tourism is a major economic driver in the area. In addition, many seasonal residents live in the area during the winter months, as temperatures in south Florida stay very moderate during that time of year.
Florida is the traditional home for Major League Baseball spring training, with teams informally organized into the "Grapefruit League." As of 2004[update], Southwest Florida hosts the following major league teams for spring training:
|County||County Seat||Pop. (2004 est.)||Pop. (2000)||Change (2000–2004)||Change (1990–2000)|
|Charlotte County||Punta Gorda||157,134||141,627||+10.9%||+27.6%|
|Collier County||East Naples||296,678||251,377||+18.0%||+65.3%|
|Glades County||Moore Haven||11,131||10,576||+5.2%||+39.3%|
|Lee County||Fort Myers||514,295||440,888||+16.6%||+31.6%|
|Florida - statewide||17,397,161||15,982,378||+8.8%%||+23.5%|
Communities listed have a population greater than 30,000 according to the 2000 census.