The DC Comics character Cyrus Gold/Solomon Grundy, a large, strong zombiesupervillain, invented as an adversary for the Green Lantern in 1944, and also a foe of Batman, was named after this nursery rhyme. He appears in the games Batman: Arkham City and Injustice: Gods Among Us, where he recites parts of the lyrics while performing certain moves. A re-invented version of Cyrus Gold appears in Arrow. Though never referred to as Solomon Grundy, John Diggle finds the Solomon Grundy poem in his apartment. When Cyrus is killed his body still showed signs of activity implying that he may become Solomon Grundy at some point.
Comic artist and writer Kaori Yuki wrote a short story centered around the poem using characters from her series God Child, which was published at the end of book five.
The premiere of Sesame Street (air date November 10, 1969) features a Solomon Grundy cartoon in which he washes only one part of the left half of his body each day. At the end of the week Solomon is still "half dirty."
Brian Dewan set the poem to music in an eponymous song on his 2001 album The Operating Theater.
Solomon Grundy, a feature film based on the poem and its structure, was released in 2013. Grundy is portrayed as a child's imaginary friend, and each of the poem's days is represented as a stage in the development of their relationship.
Solomon Grundy appears as a character (and suspect) in Jasper Fforde's novel The Big Over Easy: "'I'll be dead tired on Saturday,' he quipped to waiting journalists, 'but will bury myself in work again on Sunday.'"
The outro to The Pogues' song Billy's Bones is based on Solomon Grundy.
Solomon Grundy is mentioned in the song, "Superman's Song" by the Crash Test Dummies.