In human anatomy (female), the Skene's\ˈskēnz-\glands (also known as the lesser vestibular glands, periurethral glands, skene glands, paraurethral glands,female prostate) are glands located on the anterior wall of the vagina, around the lower end of the urethra. They drain into the urethra and near the urethral opening and may be near or a part of the G-Spot. These glands are surrounded with tissue (which includes the part of the clitoris) that reaches up inside the vagina and swells with blood during sexual arousal.
The location of the Skene's gland is the general area of the vulva, glands located on the anterior wall of the vagina around the lower end of the urethra. It has been postulated that the Skene's glands are the source of female ejaculation. In 2002, Emanuele Jannini of L'Aquila University in Italy showed that there may be an explanation both for the phenomenon and for the frequent denials of its existence. Skene's glands have highly variable anatomy, and in some extreme cases they appear to be absent entirely. If Skene's glands are the cause of female ejaculation and G-Spot-orgasms, this may explain the absence in many women.
It has been demonstrated that a large amount of lubricating fluid (filtered blood plasma[specify]) can be secreted from this gland when stimulated from inside the vagina. Some reports indicate that embarrassment regarding female ejaculation, and the mistaken notion that the substance is urine, can lead to purposeful suppression of sexual climax, leading women to seek medical advice and even undergo surgery to "stop the urine".
The Skene's glands are homologous with the prostate gland in males. The fluid that emerges during sex, female ejaculation, has a composition somewhat similar to the fluid generated in males by the prostate gland, containing biochemical markers of sexual function like human urinary protein 1 and the enzyme PDE5 where women without the gland had lower concentrations. When examined with electron microscopy, both glands show similar secretory structures, and both act similarly in terms of prostate-specific antigen and prostatic acid phosphatase studies. Because they are increasingly perceived as merely different versions of the same gland, some researchers are moving away from the name Skene's gland and are referring to it instead as the female prostate.
^Jannini E, Simonelli C, Lenzi A (2002). "Disorders of ejaculation". J Endocrinol Invest25 (11): 1006–19. PMID12553564.
^Heath D (1984). "An investigation into the origins of a copious vaginal discharge during intercourse: "Enough to wet the bed" - that "is not urine"". J Sex Res.20 (2): 194–215. doi:10.1080/00224498409551217.
^Zaviacic, M; L Danihel, M Ruzicková, J Blazeková, Y Itoh, R Okutani, T Kawai. (March 1997). "Immunohistochemical localization of human protein 1 in the female prostate (Skene's gland) and the male prostate". Histochem J.29 (3): 219–27. doi:10.1023/A:1026401909678. PMID9472384.
^Zaviacic, Z; M Ruzicková, J Jakubovský, L Danihel, P Babál, J Blazeková. (November 1994). "The significance of prostate markers in the orthology of the female prostate". Bratisl Lek Listy.95 (11): 491–7. PMID7533639.
^Wernert, N; M Albrech, I Sesterhenn, R Goebbels, H Bonkhoff, G Seitz, R Inniger, K Remberger. (1992). "The 'female prostate': location, morphology, immunohistochemical characteristics and significance". Eur Urol.22 (1): 64–9. PMID1385145.
^Tepper, SL; J Jagirdar, D Heath, SA Geller. (May 1984). "Homology between the female paraurethral (Skene's) glands and the prostate. Immunohistochemical demonstration". Arch Pathol Lab Med.108 (5): 423–5. PMID6546868.
^Pollen, JJ; A. Dreilinger (March 1984). "Immunohistochemical identification of prostatic acid phosphatase and prostate specific antigen in female periurethral glands". Urology.23 (3): 303–4. doi:10.1016/S0090-4295(84)90053-0. PMID6199882.
^Zaviacic, Z; RJ Ablin. (January 2000). "The female prostate and prostate-specific antigen. Immunohistochemical localization, implications of this prostate marker in women and reasons for using the term "prostate" in the human female". Histol Histopathol.15 (1): 131–42. PMID10668204.