Shire plc

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Shire Plc
TypePublic limited company
Traded asLSESHP, NASDAQSHPG
IndustryPharmaceuticals
Predecessor(s)Shire Pharmaceuticals Group Plc
Founded1986
HeadquartersRegistered Office: St Helier, Jersey
Corporate HQ: Dublin, Ireland
UK Operations: Basingstoke, England
Key peopleMatthew Emmens (Chairman)
Flemming Ornskov, MD (CEO)
Revenue$4,681.2 million (2012)[1]
Operating income$949.2 million (2012)[1]
Net income$745.4 million (2012)[1]
Employees5,367 (2012)[2]
Websitewww.shire.com
 
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Shire Plc
TypePublic limited company
Traded asLSESHP, NASDAQSHPG
IndustryPharmaceuticals
Predecessor(s)Shire Pharmaceuticals Group Plc
Founded1986
HeadquartersRegistered Office: St Helier, Jersey
Corporate HQ: Dublin, Ireland
UK Operations: Basingstoke, England
Key peopleMatthew Emmens (Chairman)
Flemming Ornskov, MD (CEO)
Revenue$4,681.2 million (2012)[1]
Operating income$949.2 million (2012)[1]
Net income$745.4 million (2012)[1]
Employees5,367 (2012)[2]
Websitewww.shire.com

Shire Plc is a Jersey-registered, Irish-headquartered global speciality biopharmaceutical company that is the manufacturer of pharmaceuticals.[3] Originating in the United Kingdom with a large operational base in the United States, its brands and products include Vyvanse, Adderall XR, Intuniv, Lialda, Pentasa, Fosrenol, Replagal, Elaprase, VPRIV, Firazyr and Dermagraft.

Shire has its primary listing on the London Stock Exchange and is a constituent of the FTSE 100 Index. It had a market capitalisation of approximately £11.1 billion as of 26 April 2013, making it the 37th-largest company on the London Stock Exchange.[4] Shire has a secondary listing on NASDAQ.

History[edit]

Shire was founded by Harry Stratford, Dr James Murray, Dennis Stephens, Peter Moriarty, and Geoff Hall in 1986.[5] It was first listed on the London Stock Exchange in 1996.[5] Shire's initial products were calcium supplements (Calcichew-D3) for patients seeking to treat or prevent osteoporosis. Shire's acquisitions include:

Operations[edit]

Shire develops and provides healthcare in the areas of behavioural health, gastrointestinal conditions, rare diseases, and regenerative medicine.

Products[edit]

A container of Adderall XR
NameAnnual revenue[1]Indication
Vyvanse$1,029.8MAttention Deficit Hyperactivity Disorder (ADHD)
Adderall XR$429.0MAttention Deficit Hyperactivity Disorder (ADHD)
Replagal$497.5MFabry disease (lysosomal storage disorder)
Elaprase$497.6MHunter syndrome (lysosomal storage disorder)
Lialda/Mezavant$399.9MGastrointestinal (Ulcerative colitis)
VPRIV$306.6MType 1 Gaucher disease
Pentasa$265.8MGastrointestinal (Ulcerative colitis)
Intuniv$287.8MAttention Deficit Hyperactivity Disorder (ADHD)
Fosrenol$172.0MRenal disease
Dermagraft$153.8MDiabetic Foot Ulcers (“DFU”)
Firazyr$116.3M(Hereditary angioedema)
Other (including Xagrid, Equasym, and Resolor)$250.6M

Royalty income[edit]

NameAnnual revenue[1]IndicationLicensee
Adderall XR$70.3MAttention Deficit Hyperactivity Disorder (ADHD)Imapx and Teva
3TC (Lamivudine) and Zeffix (Lamivudine)$91.6MHIV and Chronic hepatitis BGlaxoSmithKline
Fosrenol$53.3MRenal diseaseBayer Yakuhin
Other$26.4M

Locations[edit]

The original corporate head quarters and still major operation base are located in Basingstoke, Hampshire, England. Other major offices are located in the United States in Wayne, Pennsylvania and Cambridge, Massachusetts. In addition, Shire owns a manufacturing site in Lexington, Massachusetts and San Diego, California. It announced in November 2013 that it would be further reducing its presence in the UK. [19]

Tax Avoidance[edit]

In 2008, in reaction to new taxation measures announced by the Labour Party in the treatment of royalties on patents, the company moved its tax domicile to Dublin, Ireland.[20] Effected through the creation of a new holding company in St Helier, Jersey in the Channel Islands, it will pay reduced tax on global earnings, where royalties on patents lodged in Ireland are tax free.

Corporate leadership[edit]

The non-executive Board chairman is Matthew Emmens. Flemming Ornskov, MD, chief executive officer. Graham Hetherington, chief financial officer.

See also[edit]

References[edit]

  1. ^ a b c d e "Preliminary Results 2012" (PDF). Retrieved 18 March 2013. 
  2. ^ 10K Report
  3. ^ "Contact Us". Shire plc. Retrieved 3 January 2010. 
  4. ^ "FTSE All-Share Index Ranking". stockchallenge.co.uk. Retrieved 30 April 2013. 
  5. ^ a b How Shire evolved
  6. ^ Shire buys US drugs delivery firm for pounds 105m The Independent, 26 February 1997
  7. ^ Investment Column: Shire focuses on buying Richwood The Independent, 5 August 1997
  8. ^ Canadians give go-ahead for Shire takeover of BioChem The Telegraph, 10 May 2001
  9. ^ U.K. drug maker agrees to buy Transkaryotic Wall Street Journal, 2005
  10. ^ Shire buys New River Pharmaceuticals for $2.6 billion Pharma Times, 21 February 2007
  11. ^ Shire to buy Jerini in $521M deal Fierce Biotech, 3 July 2008
  12. ^ Shire forges $565M buyout deal for Movetis Fierce Biotech, 3 August 2010
  13. ^ Shire swoops to buy Advanced BioHealing Pharma Times, 18 May 2011
  14. ^ Shire to buy U.S. biotech firm for up to $325 million Reuters, 15 March 2012
  15. ^ Shire Acquires Lotus Tissue Repair, Inc. Shire.com, 8 January 2013
  16. ^ Shire Acquires Premacure AB Shire.com, 12 March 2013
  17. ^ Shire to Acquire SARcode Bioscience, Expands Presence in Ophthalmology Shire.com, 25 March 2013
  18. ^ [1] Bloomberg.com, 11 November 2013
  19. ^ "Shire delivers fresh blow to UK life sciences". Financial Times. 10 November 2013. Retrieved 8 December 2013. 
  20. ^ Shire moves to Ireland for tax Irish Examiner, April 2008

External links[edit]