Sermorelin

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Sermorelin
Systematic (IUPAC) name
L-Tyrosyl-L-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide
Clinical data
Trade namesGeref
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy cat.
Legal status
  • US: Discontinued
RoutesInjection
Identifiers
CAS number86168-78-7 YesY
ATC codeH01AC04 V04CD03
PubChemCID 16132413
DrugBankDB00010
ChemSpider17289071 N
UNII89243S03TE N
KEGGD08509 YesY
ChEMBLCHEMBL1201490 N
SynonymsGRF 1–29
Chemical data
FormulaC149H246N44O42S 
Mol. mass3357.882 g/mol
 N (what is this?)  (verify)
 
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Sermorelin
Systematic (IUPAC) name
L-Tyrosyl-L-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-asparaginyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucylglycyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-methionyl-L-seryl-L-argininamide
Clinical data
Trade namesGeref
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy cat.
Legal status
  • US: Discontinued
RoutesInjection
Identifiers
CAS number86168-78-7 YesY
ATC codeH01AC04 V04CD03
PubChemCID 16132413
DrugBankDB00010
ChemSpider17289071 N
UNII89243S03TE N
KEGGD08509 YesY
ChEMBLCHEMBL1201490 N
SynonymsGRF 1–29
Chemical data
FormulaC149H246N44O42S 
Mol. mass3357.882 g/mol
 N (what is this?)  (verify)

Sermorelin (trade name is Geref) is a growth hormone releasing hormone (GHRH) analogue. It is a 29-amino acid polypeptide representing the 1–29 fragment from endogenous human growth hormone releasing hormone, and is thought to be the shortest fully functional fragment of GHRH.[1] It is used as a test for growth hormone secretion.[2] It is also used as doping substance in sports.[citation needed]

See also[edit]

References[edit]

  1. ^ Prakash A, Goa KL (August 1999). "Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency". BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy 12 (2): 139–57. doi:10.2165/00063030-199912020-00007. PMID 18031173. 
  2. ^ Pharmacology (Rang, Dale, Ritter & Moore, ISBN 0-443-07145-4, 5th ed., Churchill Livingstone 2003).