He has acted in many popular movies with several of the leading actors and comedians in the south Indian cine industry.His first movie was Pasi (1979) in which he played a non comedic role. He usually appears in films with Goundamani in a slapstickdouble act. Together they have formed a comic pair in many Tamil films. Recently, Senthil has started acting in Tamil teleserials.
He along with Koundamani was known as the Laurel and hardy of Tamil Cinema.
He was born on 23 March 1951 in a small village called Ilanjambore near Mudukulathur in Ramanathapuram District. His parents were Ramamoorthi and Thirukammal. He ran away from his village at the age 12 due to his father's scolding. He first joined an oil mart, then a private wine shop as bar attender and then landed up in drama where he started developing his skills. He slowly entered the Tamil film industry in small characters and finally landed a good role in the movie Malayoor Mambattiyan. He married Kalaiselvi in 1984. He has two sons, Dr. Manikanda Prabhu and Hemachandra Prabhu.