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Cadell has been appearing on British television, film, and theatre over the last thirty years. She has taken on a wide range of supporting and leading roles. Recently, she has played Dorothy Crowther in The Amazing Mrs Pritchard; Mrs Tishell in Doc Martin; and the Dean Mieke Miedema in Lab Rats. She appeared in Sam Mendes' Broadway production of Anton Chekhov's The Cherry Orchard, and played Maria in Mendes' highly acclaimed production of Twelfth Night for the Donmar Warehouse (London and New York).
In 2013, she appeared as both Sister Gregory, a Roman Catholic nun, in the Father Brown episode "The Bride of Christ". She played the title role as the vanishing lady herself, Miss Froy, the character previously played by Dame May Whitty and Angela Lansbury in previous two versions, in the 2013 TV film The Lady Vanishes from the BBC, directed by Diarmuid Lawrence from an updated screenplay by Fiona Seres.
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