The word scruples or scruple can mean:
- scruple – a doubt or hesitation that troubles the conscience or that comes from the difficulty of determining whether something is right
- scrupulosity – obsessive concern with one's own sins and compulsive performance of religious devotion. Formerly this was called scruples or religious scruples, but now it is generally called scrupulosity.
- A unit of apothecary weight, with symbol ℈. It is a twenty-fourth part of an ounce, or 20 grains, or approximately 1.3 grams. More generally, any small quantity might be called a scruple.
- Scruples, a 1978 novel by Judith Krantz
- Scruples, 1980 television miniseries based on the novel and starring Lindsay Wagner
- Scruples, a 1984 board game by Henry Makow based on ethical dilemmas