Snyder graduated from Brown University in 1998 with a degree in creative writing, and then worked at Walt Disney World for about a year. Snyder's Disney World stint strongly influenced his writing; he later recalled, "it did a world of good for my writing...All the things I ended up writing about, those things that are deeply frightening to me—fear of commitment and growing up, fear of losing loved ones, the wonder and terror of falling in love—all of it was constantly being played out all around me in this weird, cartoonish, magnified way at Disney."
In 2009, Snyder began writing for Marvel Comics. His first foray into the genre was a one-shot focusing on the first Human Torch, part of Marvel's 70th anniversary celebrations. He later wrote the 4-issue miniseries, Iron Man: Noir, which debuted in April 2010.
Vertigo began publishing American Vampire, Snyder's first creator-owned ongoing series, in March 2010. The first five issues feature an original storyline by Stephen King.American Vampire won the 2011 Eisner Award for Best New Series, as well as the 2011 Harvey Award for Best New Series.
Since September 2011, Snyder has been writing both Batman and a new Swamp Thing ongoing series as part of The New 52, DC Comics' company-wide relaunch of all of its titles. Snyder will co-write Talon, a spin-off of the "Court of Owls" storyline in Batman, which will focus on a rogue Talon from the Court.
It was announced at the New York Comic Con 2012 that Snyder would be writing a new Superman ongoing series, titled Superman Unchained, with art by Jim Lee. The series began publication in June 2013.
In May 2013 Vertigo premiered The Wake, a 10-issue, ocean-based horror miniseries written by Snyder and drawn by Snyder's American Vampire: Survival Of The Fittest collaborator Sean Murphy. The series follows marine biologist Lee Archer, who along with the Department of Homeland Security, discovers a potential threat to humanity that may involve strange, humanoid creatures that inhabit the ocean depths. The story shifts between three time periods: the near future, two centuries in the future and the distant past. The covers of the first five issues form a mural when placed side by side.
The same month, DC published a Free Comic Book Day sneak preview of Superman Unchained, an ongoing series written by Snyder and illustrated by Jim Lee, which was later published on June 12, 2013, and intended to coincide with the feature film Man of Steel, which opened two days later. Snyder explained his approach to the series: "The way to approach a character as iconic as him is you just come at it from a standpoint of what you love the most about the character, and then write a story that explores that, tear it down and build it back up."
^Watson, Sasha (September 27, 2010). "A Literary Imagination Goes Graphic". Publishers Weekly. Archived from the original on April 1, 2012. Retrieved April 1, 2012. "In a creative writing class that Scott Snyder teaches at NYU, "The Monster Under Your Story," students discuss the intersections of literary fiction, genre fiction, and comics."
^Cowsill, Alan; Dolan, Hannah, ed. (2010). "2000s". DC Comics Year By Year A Visual Chronicle. Dorling Kindersley. p. 340. ISBN978-0-7566-6742-9. "The first five double-sized issues consisted of two stories, illustrated by Rafael Albuquerque. Scott Snyder wrote each issue's lead feature, and Stephen King wrote the back-up tales."
^Rogers, Vaneta (June 8, 2012). "DC Adds Four to New 52, Including DiDio's Phantom Stranger". Newsarama. Archived from the original on June 10, 2012. Retrieved June 10, 2012. "This new comic...introduces a new "anti-hero on the run" to the DCU. Calvin Rose, the only Talon to escape from the control of the Court of Owls, will be traveling all around the DCU as he is hunted by his former masters. While the story spins out of the Court of Owls storyline that is running through the first year of Snyder's Batman, the title character is a brand new one."