Christian Friedrich Samuel Hahnemann was born in Meissen, Saxony, near Dresden. His father,was a painter and designer of porcelain, for which the town of Meissen is famous.
As a young man, Hahnemann became proficient in a number of languages, including English, French, Italian, Greek and Latin. He eventually made a living as a translator and teacher of languages, gaining further proficiency in "Arabic, Syriac, Chaldaic and Hebrew".
Hahnemann studied medicine for two years at Leipzig. Citing Leipzig's lack of clinical facilities, he moved to Vienna, where he studied for ten months. After one term of further study, he graduated MD at the University of Erlangen on 10 August 1779, qualifying with honors. His poverty may have forced him to choose Erlangen, as the school's fees were lower. Hahnemann's thesis was titled Conspectus adfectuum spasmodicorum aetiologicus et therapeuticus. [A Dissertation on the Causes and Treatment of Cramps]
In 1781, Hahnemann took a village doctor's position in the copper-mining area of Mansfeld, Saxony. He soon married Johanna Henriette Kuchler and would eventually have eleven children. After abandoning medical practice, and while working as a translator of scientific and medical textbooks, Hahnemann travelled around Saxony for many years, staying in many different towns and villages for varying lengths of time, never living far from the River Elbe and settling at different times in Dresden, Torgau, Leipzig and Köthen (Anhalt) before finally moving to Paris in June 1835.
Hahnemann was dissatisfied with the state of medicine in his time, and particularly objected to practices such as bloodletting. He claimed that the medicine he had been taught to practice sometimes did the patient more harm than good:
My sense of duty would not easily allow me to treat the unknown pathological state of my suffering brethren with these unknown medicines. The thought of becoming in this way a murderer or malefactor towards the life of my fellow human beings was most terrible to me, so terrible and disturbing that I wholly gave up my practice in the first years of my married life and occupied myself solely with chemistry and writing.
After giving up his practice around 1784, Hahnemann made his living chiefly as a writer and translator, while resolving also to investigate the causes of medicine's alleged errors. While translating William Cullen's A Treatise on the Materia Medica, Hahnemann encountered the claim that cinchona, the bark of a Peruvian tree, was effective in treating malaria because of its astringency. Hahnemann believed that other astringent substances are not effective against malaria and began to research cinchona's effect on the human body by self-application. Noting that the drug induced malaria-like symptoms in himself, he concluded that it would do so in any healthy individual. This led him to postulate a healing principle: "that which can produce a set of symptoms in a healthy individual, can treat a sick individual who is manifesting a similar set of symptoms." This principle, like cures like, became the basis for an approach to medicine which he gave the name homeopathy. He first used the term homeopathy in his essay Indications of the Homeopathic Employment of Medicines in Ordinary Practice, published in Hufeland's Journal in 1807.
Hahnemann tested substances for the effect they produced on a healthy individual and tried to deduce from this the ills they would heal. From his research, he initially concluded that ingesting substances to produce noticeable changes in the body resulted in toxic effects. He then attempted to mitigate this problem through exploring dilutions of the compounds he was testing. He claimed that these dilutions, when prepared according to his technique of succussion (systematic mixing through vigorous shaking) and potentization, were still effective in alleviating the same symptoms in the sick.
Hahnemann began practicing this new technique, which attracted other doctors c.1792. He first published an article about the homeopathic approach in a German-language medical journal in 1796. Following a series of further essays, he published in 1810 "Organon of the Rational Art of Healing", followed over the years by four further editions entitled The Organon of the Healing Art, the first systematic treatise and containing all his detailed instructions on the subject. A 6th Organon edition, unpublished during his lifetime, and dating from February 1842, was only published many years after his death. It consisted of a 5th Organon containing extensive handwritten annotations. (A reading of each edition will demonstrate the extent of the revision and experience based additions.) The Organon is widely regarded as a remodelled form of an essay he published in 1806 called "The Medicine of Experience", which had been published in Hufeland's Journal. Of the Organon, Dudgeon states it "was an amplification and extension of his "Medicine of Experience", worked up with greater care, and put into a more methodical and aphoristic form, after the model of the Hippocratic writings." 
Around the start of the 19th century Hahnemann developed a theory, propounded in his 1803 essay On the Effects of Coffee from Original Observations, that many diseases are caused by coffee. Hahnemann later abandoned the coffee theory in favour of the theory that disease is caused by psora, but it has been noted that the list of conditions Hahnemann attributed to coffee was similar to his list of conditions caused by psora.
In early 1811 Hahnemann moved his family back to Leipzig with the intention of teaching his new medical system at the University of Leipzig. As required by the university statutes, to become a faculty member he was required to submit and defend a thesis on a medical topic of his choice. On 26 June 1812, Hahnemann presented a Latin thesis, entitled "A Medical Historical Dissertation on the Helleborism of the Ancients." His thesis very thoroughly examined the historical literature and sought to differentiate between the ancient use of Helleborus niger, or black hellebore and the medicinal uses of the "white hellebore", botanically Veratrum album, both of which are poisonous plants.
Hahnemann continued practicing and researching homeopathy, as well as writing and lecturing for the rest of his life. He died in 1843 in Paris, at 88 years of age, and is entombed in a mausoleum at Paris's Père Lachaise Cemetery.
There are a few living descendants of Hahnemann's older sister Charlotte (1752–1812), but the living descendants of Hahnemann himself derive from one of his daughters.
Hahnemann's daughter, Amelie (1789–1881), had a son: Dr. Leopold Suss-Hahnemann. Leopold emigrated to England, and he practised homeopathy in London. He retired to the Isle of Wight and died there at the outbreak of World War I in 1914. Dr Leopold Suss-Hahnemann's youngest daughter, Amalia had two children, Winifred (born in 1898) and Herbert. William Herbert Tankard-Hahnemann (1922–2009) was Winifred's son. He served as a Major in the British Army during World War II, and then had a career in the city of London. He was at one point appointed as a Freeman of the City of London. Mr William Herbert Tankard-Hahnemann, the great, great, great grandson of Samuel Hahnemann died on 12 January 2009 (his 87th birthday) after 22 years of active patronage of the British Institute of Homeopathy. The William Tankard-Hahnemann line continues with his son, Charles.
Hahnemann wrote a number of books, essays, and letters on the homeopathic method, chemistry, and general medicine:
The Organon of the Healing Art (1810), a detailed delineation of what he saw as the rationale underpinning homeopathic medicine, and guidelines for practice. Hahnemann published the 5th edition in 1833; a revised draft of this (1842) was discovered after Hahnemann's death and finally published as the 6th edition in 1921.
Materia Medica Pura, a compilation of "homoeopathic proving" reports, published in six volumes between vol. I in 1811 and vol. VI in 1827. Revised editions of volumes I and II were published in 1830 and 1833, respectively.
Chronic Diseases (1828), an explanation of the root and cure of chronic disease according to the theory of miasms, together with a compilation of "homoeopathic proving" reports, published in five volumes during the 1830s.
The Friend of Health, in which Hahnemann "recommended the use of fresh air, bed rest, proper diet, sunshine, public hygiene and numerous other beneficial measures at a time when many other physicians considered them of no value."
Appeal to Thinking Philanthropist Respecting the Mode of Propagation of the Asiatic Choler, in which Hahnemann describes cholera physicians and nurses as the "certain and frequent propagators" of cholera and that whilst deriding nurses' "fumigations with chlorine", promoted the use of "drops of camphorated spirit" as a cure for the disease.
Hahnemann also campaigned for the humane treatment of the insane in 1792
John Henry Clarke wrote that "In 1787, Hahnemann discovered the best test for arsenic and other poisons in wine, having pointed out the unreliable nature of the "Wurtemberg test," which had been in use up to that date." 
^Though some sources do state that he was born in the early hours of 11 April 1755, Haehl, Richard (1922). Samuel Hahnemann his Life and Works1. p. 9. "Hahnemann, was born on 10 April at approximately twelve o'clock midnight."
^Harris Livermore Coulter (1977). Divided Legacy, a History of the Schism in Medical ThoughtII. Washington: Wehawken Books. p. 306. ISBN0-916386-02-3. OCLC67493911.
Brockmeyer, Bettina (2007). "Representations of illness in letters addressed to Samuel Hahnemann: gender and historical perspectives". Medizin, Gesellschaft, und Geschichte : Jahrbuch des Instituts für Geschichte der Medizin der Robert Bosch Stiftung (in German) 29: 211–221, 259. PMID18354994.
Kayne, Steven (2006). "Samuel Hahnemann (1755–1843): the founder of modern homeopathy.". Pharmaceutical historian36 (2 Suppl): S23–6. PMID17153748.
Brockmeyer, Bettina (2005). "Writing about oneself and others: men and women in letters to doctor Samuel Hahnemann 1831–1835". Würzburger medizinhistorische Mitteilungen / im Auftrage der Würzburger medizinhistorischen Gesellschaft und in Verbindung mit dem Institut für Geschichte der Medizin der Universität Würzburg (in German) 24: 18–28. PMID17153289.
"Biographic synopsis on Samuel Hahnemann". Revista de enfermería (Barcelona, Spain) (in Spanish) 28 (3): 10–16. 2005. PMID15871338.
Eschenbruch, Nicholas (2005). "Rationalist, magician, scharlatan? Samuel Hahnemann and homeopathy from the viewpoint of homeopathy". Schweiz. Rundsch. Med. Prax. (in German) 94 (11): 443–446. PMID15822443.
Jutte, R. (1999). ""Thus it passes from the patient's purse into that of the doctor without causing displeasure" – Samuel Hahnemann and medical fees". Medizin, Gesellschaft, und Geschichte : Jahrbuch des Instituts für Geschichte der Medizin der Robert Bosch Stiftung (in German) 18: 149–167. PMID11624613.
de Goeij, C. M. (1994). "Samuel Hahnemann: an indignant systems builder". Nederlands tijdschrift voor geneeskunde (in Dutch) 138 (6): 310–314. PMID8121514.
Rizza, E. (1994). "Samuel Hahnemann: a mystical empiricist. A study of the origin and development of the homeopathic medical system". Medicina nei secoli (in Italian) 6 (3): 515–524. PMID11620590.
Meissner, M. (1992). "Samuel Hahnemann—the originator of homeopathic medicine". Krankenpflege Journal30 (7–8): 364–366. PMID1405462.
Schmidt, J. M. (1988). "The publications of Samuel Hahnemann". Sudhoffs Archiv72 (1): 14–36. PMID2970128.
Lozowski, J. (1982). "Homeopathy (Samuel Hahnemann)". Pielȩgniarka i połozna (in Polish) (4–5): 16–17. PMID6750668.
Habacher, M. (1980). "Homöopathische Fernbehandlung durch Samuel Hahnemann". Medizinhistorisches Journal (in German) 15 (4): 385–391. PMID11610925.
Antall, J.; Kapronczay, K. (1973). "Samuel Hahnemann". Orvosi hetilap114 (32): 1945–1947. PMID4581537.
Hodges, P. C. (1964). "Homeopathy and Christian Friedrich Samuel Hahnemann". Postgraduate Medicine35: 666–668. PMID14143315.
Dietrich, H. J. (1958). "Hahnemann's capacity for greatness; Samuel Hahnemann; and Hahnemann Medical College". The Hahnemannian93 (2): 35–39. PMID13562700.
Koch, E. (1955). "On the 200th anniversary of Dr. Samuel Hahnemann; several ideas concerning homeopathy". Das Deutsche Gesundheitswesen (in German) 10 (16): 585–590. PMID14379841.
Auster, F. (1955). "200th Anniversary of the birth of Dr. Samuel Hahnemann, born April 10, 1755". Pharmazeutische Zentralhalle für Deutschland (in German) 94 (4): 124–128. PMID14384489.