Salsalate is used to reduce pain and inflammation caused by conditions such as rheumatoid arthritis, osteoarthritis, and related rheumatic conditions. Salsalate is also recommended by physicians as an anti-inflammatory alternative to naproxen, and ibuprofen for patients that have had minor stomach bleeding or stomach upset. It has also been used as an alternative to narcotic pain medicine for people with spinal disc protrusion.
"In contrast to aspirin, salsalate causes no greater fecal gastrointestinal blood loss than placebo." 
Diabetes Mellitus Research
Salsalate has been proposed as a useful medication in the prevention or treatment of type 2 diabetes mellitus due to its ability to lower insulin resistance and may be useful in prediabetes. Salsalate had been suggested as possible treatment for diabetes as early as 1876. The anti-inflammatory property of salsalate may reverse the chronic inflammation thought to be the cause of diabetes in the obese. However, the efficacy of salsalate to prevent the progression from prediabetes to type 2 diabetes mellitus has only been examined in a few studies.
On March 20, 2010, The Joslin Diabetes Center, Boston, MA, released a report entitled: Generic Drug for Type 2 Diabetes Passes Next Clinical Hurdle - "Salsalate, an anti-inflammatory agent, shows encouraging results in preliminary trial"