Regeneron

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Regeneron Pharmaceuticals, Inc.
TypePublic
Traded asNASDAQREGN
IndustryPharmaceuticals; Biotech
Founded1988
HeadquartersTarrytown, New York, US (Headquarters)
Area servedWorldwide
Key people
Revenue
Operating income
  • Increase US$00.76 billion (2013)[1]:F-3
  • Increase US$00.46 billion (2012)[1]:F-3
Total assets
  • Increase US$03.0 billion (2013)[1]:F-2
  •     US$02.1 billion (2012)[1]:F-2
Total equity
  • Increase US$02.0 billion (2013)[1]:48
  • Increase US$01.2 billion (2012)[1]:48
Websitewww.regeneron.com
 
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Regeneron Pharmaceuticals, Inc.
TypePublic
Traded asNASDAQREGN
IndustryPharmaceuticals; Biotech
Founded1988
HeadquartersTarrytown, New York, US (Headquarters)
Area servedWorldwide
Key people
Revenue
Operating income
  • Increase US$00.76 billion (2013)[1]:F-3
  • Increase US$00.46 billion (2012)[1]:F-3
Total assets
  • Increase US$03.0 billion (2013)[1]:F-2
  •     US$02.1 billion (2012)[1]:F-2
Total equity
  • Increase US$02.0 billion (2013)[1]:48
  • Increase US$01.2 billion (2012)[1]:48
Websitewww.regeneron.com

Regeneron Pharmaceuticals, Inc. is a biotechnology company headquartered in Tarrytown, in New York, US The company was founded in 1988.[3] Originally focused on neurotrophic factors and their regenerative capabilities (thus the name), it branched out into the study of both cytokine and tyrosine kinase receptors.

Regeneron has two products in development based on aflibercept, a VEGF inhibitor, and rilonacept, an interleukin-1 blocker. VEGF is a protein that normally stimulates the growth of blood vessels, and interleukin-1 is a protein that is normally involved in inflammation. On March 26, 2012 Bloomberg announced that Sanofi and Regeneron are in development with a new cholesterol drug which will help reduce cholesterol up to 72% more than the leading brands, this new drug will greatly reduce heart disease in patients around the world. The medicine, one in a class of drugs targeting the PCSK9 gene, reduced patients’ average LDL cholesterol levels to as little as 34 milligrams per deciliter after 12 weeks in the mid- stage study, presented today at the American College of Cardiology meeting in Chicago.

Marketed products[edit]

EYLEA (aflibercept injection): Approved by the U.S. Food and Drug Administration (FDA) in November 2011.[3][4] EYLEA developed to treat a common cause of blindness in the elderly.

ARCALYST (rilonacept) Injection for Subcutaneous Use: Approved by the FDA in February 2008.

ZALTRAP for metastatic colorectal cancer: Approved by the FDA in August 2012.[5]

Technology platforms[edit]

Trap Fusion Proteins: Regeneron’s novel and patented Trap technology creates high-affinity product candidates for many types of signaling molecules, including growth factors and cytokines. The Trap technology involves fusing two distinct fully human receptor components and a fully human immunoglobulin-G constant region.

Fully Human Monoclonal Antibodies: Regeneron has developed a suite (VelociSuite) of patented technologies, including VelocImmune and VelociMab, that allow Regeneron scientists to determine the best targets for therapeutic intervention and rapidly generate high-quality, fully human antibodies drug candidates addressing these targets.

References[edit]

  1. ^ a b c d e f g "Regeneron Pharmaceuticals, Inc. (2013)". EDGAR. Form 10-K. U.S. Securities and Exchange Commission. February 13, 2014. Commission File Number 0-19034. Retrieved March 22, 2014. 
  2. ^ "Regeneron Reports Fourth Quarter and Full Year 2012 Financial and Operating Results" (Press release). Regeneron. February 14, 2013. Archived from the original on June 4, 2013. Retrieved March 22, 2014. 
  3. ^ a b Herper, Matthew (August 14, 2013). "How Two Guys From Queens Are Changing Drug Discovery". Forbes (United States). Archived from the original on March 16, 2014. Retrieved March 22, 2014. open access publication - free to read
  4. ^ "Regulators Approve a Drug for an Eye Condition". The New York Times. Associated Press. November 18, 2011. (registration required)
  5. ^ "FDA approves Zaltrap for metastatic colorectal cancer" (Press release). U.S. Food and Drug Administration. August 3, 2012. Archived from the original on June 25, 2013. 

External links[edit]