Pituitary adenoma

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Pituitary adenoma
Classification and external resources
Adenome hypophyse.JPG
ICD-10D35.2
ICD-9237.0
ICD-O:M8272/0
MedlinePlus000704
eMedicineneuro/312
MeSHD010911
 
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Pituitary adenoma
Classification and external resources
Adenome hypophyse.JPG
ICD-10D35.2
ICD-9237.0
ICD-O:M8272/0
MedlinePlus000704
eMedicineneuro/312
MeSHD010911

Pituitary adenomas are tumors that occur in the pituitary gland. Pituitary adenomas are generally divided into three categories dependent upon their biological functioning: benign adenoma, invasive adenoma, and carcinomas, with carcinomas accounting for 0.1% to 0.2%, approximately 35% being invasive adenomas and most being benign adenomas. Pituitary adenomas represent from 10% to 25% of all intracranial neoplasms[citation needed] and the estimated prevalence rate in the general population is approximately 17%.[1]

Non-invasive and non-secreting pituitary adenomas are considered to be benign in the literal as well as the clinical sense; however a recent meta-analysis (Fernández-Balsells, et al. 2011) of available research has shown there are to date scant studies - of poor quality - to either support or refute this assumption.

Adenomas which exceed 10 millimetres (0.39 in) in size are defined as macroadenomas, with those smaller than 10 mm referred to as microadenomas. Most pituitary adenomas are microadenomas, and have an estimated prevalence of 16.7% (14.4% in autopsy studies and 22.5% in radiologic studies).[1][2] A majority of pituitary microadenomas often remain undiagnosed and those that are diagnosed are often found as an incidental finding, and are referred to as incidentalomas.

Pituitary macroadenomas are the most common cause of hypopituitarism, and in the majority of cases they are non-secreting adenomas.[3]

Invasive adenomas may invade the dura mater, cranial bone, or sphenoid bone. Although previously believed that clinically active pituitary adenomas were rare, recent studies have suggested that they may affect approximately one in 1000 of the general population.[4]

Overview[edit]

Pituitary gland

The pituitary gland or hypophysis is often referred to as the "master gland" of the human body. Part of the hypothalamic-pituitary axis, it controls most of the body's endocrine functions via the secretion of various hormones into the circulatory system. The pituitary gland is located below the brain in a depression (fossa) of the sphenoid bone known as the sella turcica. Although anatomically and functionally connected to the brain, the pituitary gland[5] sits outside the blood–brain barrier. It is separated from the subarachnoid space by the diaphragma sella, therefore the arachnoid mater and thus cerebral spinal fluid cannot enter the sella turcica.

The pituitary gland is divided into two lobes, the anterior lobe (which accounts for two thirds of the volume of the gland), and the posterior lobe (one third of the volume) separated by the pars intermedia.

The posterior lobe (the neural lobe or neurohypophysis) of the pituitary gland is not, despite its name, a true gland. The posterior lobe contains axons of neurons that extend from the hypothalamus to which it is connected via the pituitary stalk. The hormones vasopressin and oxytocin, produced by the neurons of the supraoptic and paraventricular nuclei of the hypothalamus, are stored in the posterior lobe and released from axon endings (dendrites) within the lobe.[6]

The pituitary gland's anterior lobe (adenohypophysis) is a true gland which produces and secretes six different hormones: thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), growth hormone (GH), and prolactin (PRL).[7]

Classification[edit]

Pituitary adenomas are classified based on upon anatomical, histological and functional criteria.[8]

Classification based on radioanatomical findings places adenomas into 1 of 4 grades (I–IV):[9]
Stage I: microadenomas (<1 cm) without sella expansion.
Stage II: macroadenomas (≥1 cm) and may extend above the sella.
Stage III: macroadenomas with enlargement and invasion of the floor or suprasellar extension.
Stage IV is destruction of the sella.
Type of adenomaSecretionStainingPathologyPercentage of hormone production cases
lactotrophic adenomas (prolactinomas)secrete prolactinacidophilicgalactorrhea, hypogonadism, amenorrhea, infertility, and impotence30%[11]
somatotrophic adenomassecrete growth hormone (GH)acidophilicacromegaly in adults; gigantism in children15%[11]
corticotrophic adenomassecrete adenocorticotropic hormone (ACTH)basophilicCushing's disease
gonadotrophic adenomassecrete luteinizing hormone (LH), follicle-stimulating hormone (FSH) and their subunitsbasophilicusually doesn't cause symptoms10%[11]
thyrotrophic adenomas (rare)secrete thyroid-stimulating hormone (TSH)basophilic to chromophobicoccasionally hyperthyroidism,[12] usually doesn't cause symptomsLess than 1%[11]
null cell adenomasdo not secrete hormonesmay stain positive for synaptophysin25% of pituitary adenomas are nonsecretive[11]

Pituitary incidentalomas[edit]

Pituitary incidentalomas are pituitary tumors that are characterized as an incidental finding. They are often discovered by computed tomography (CT) or magnetic resonance imaging (MRI), performed in the evaluation of unrelated medical conditions such as suspected head trauma, in cancer staging or in the evaluation of nonspecific symptoms such as dizziness and headache. It is not uncommon for them to be discovered at autopsy. In a meta-analysis, adenomas were found in an average of 16.7% in postmortem studies, with most being microadenomas (<10mm); macrodenomas accounted for only 0.16% to 0.2% of the decedents.[1] While non-secreting, noninvasive pituitary microadenomas are generally considered to be literally as well as clinically benign, there are to date scant studies of low quality to support this assertion.[13]

It has been recommended in the current Clinical Practice Guidelines (2011) by the Endocrine Society - a professional, international medical organization in the field of endocrinology and metabolism - that all patients with pituitary incidentalomas undergo a complete medical history and physical examination, laboratory evaluations to screen for hormone hypersecretion and for hypopituitarism. If the lesion is in close proximity to the optic nerves or optic chiasm, a visual field examination should be performed. For those with incidentalomas which do not require surgical removal, follow up clinical assessments and neuroimaging should be performed as well follow-up visual field examinations for incidentalomas that abut or compress the optic nerve and chiasm and follow-up endocrine testing for macroincidentalomas.[14]

Ectopic pituitary adenoma[edit]

An ectopic (occurring in an abnormal place) pituitary adenoma is a rare type of tumor which occurs outside of the sella turcica, most often in the sphenoid sinus,[15] suprasellar region, nasopharynx and the cavernous sinuses.[16]

Metastases to the pituitary gland[edit]

Carcinomas that metastasize into the pituitary gland are uncommon and typically seen in the elderly,[17][18] with lung and breast cancers being the most prevalent,[19] In breast cancer patients, metastases to the pituitary gland occur in approximately 6-8% of cases.[20]

Symptomatic pituitary metastases account for only 7% of reported cases. In those who are symptomatic Diabetes insipidus often occurs with rates approximately 29-71%. Other commonly reported symptoms include anterior pituitary dysfunction, visual field defects, headache/pain, and ophthalmoplegia.[21]

Risk factors[edit]

Multiple endocrine neoplasia[edit]

Adenomas of the anterior pituitary gland are a major clinical feature of multiple endocrine neoplasia type 1 (MEN1), a rare inherited endocrine syndrome that affects 1 person in every 30,000. MEN causes various combinations of benign or malignant tumors in various glands in the endocrine system or may cause the glands to become enlarged without forming tumors. It often affects the parathyroid glands, pancreatic islet cells, and anterior lobe of the pituitary gland. MEN1 may also cause non-endocrine tumors such as facial angiofibromas, collagenomas, lipomas, meningiomas, ependymomas, and leiomyomas. Approximately 25 percent of patients with MEN1 develop pituitary adenomas.[22][23]

Carney complex[edit]

Carney complex (CNC), also known as LAMB syndrome[24] and NAME syndrome[24] is an autosomal dominant condition comprising myxomas of the heart and skin, hyperpigmentation of the skin (lentiginosis), and endocrine overactivity and is distinct from Carney's triad.[25][26] Approximately 7% of all cardiac myxomas are associated with Carney complex.[27] Patients with CNC develop growth hormone (GH)-producing pituitary tumors and in some instances these same tumors also secrete prolactin. There are however no isolated prolactinomas or any other type of pituitary tumor. In some patients with CNC, the pituitary gland is characterized by hyperplastic areas with the hyperplasia most likely preceding the formation of GH-producing adenomas.[28]

Familial isolated pituitary adenoma[edit]

Familial isolated pituitary adenoma (FIPA) is a term that used to identify a condition that displays an autosomal dominant inheritance and is characterised by the presence of two or more related patients affected by adenomas of the pituitary gland only, with no other associated symptoms that occur in Multiple endocrine neoplasia Type 1 or Carney complex.[29][30]

Symptoms[edit]

Physical[edit]

Binocular image with the outer halves of each circle removed
Visual field loss in bitemporal hemianopsia: peripheral vision loss affecting both eyes, resulting from a tumor-typically a pituitary adenoma- putting pressure on the optic chiasm.

Hormone secreting pituitary adenomas cause one of several forms of hyperpituitarism. The specifics depend on the type of hormone. Some tumors secrete more than one hormone, the most common combination being GH and prolactin.

A pituitary adenoma may present with visual field defects, classically bitemporal hemianopsia. It arises from the compression of the optic nerve by the tumor. The specific area of the visual pathway at which compression by these tumours occurs is at the optic chiasma.

The anatomy of this structure causes pressure on it to produce a defect in the temporal visual field on both sides, a condition called bitemporal hemianopsia. If originating superior to the optic chiasm, more commonly in a craniopharyngioma of the pituitary stalk, the visual field defect will first appear as bitemporal inferior quadrantanopia, if originating inferior to the optic chiasm the visual field defect will first appear as bitemporal superior quadrantanopia. Lateral expansion of a pituitary adenoma can also compress the abducens nerve, causing a lateral rectus palsy.

Also, a pituitary adenoma can cause symptoms of increased intracranial pressure.

Prolactinomas often start to give symptoms especially during pregnancy, when the hormone progesterone increases the tumor's growth rate.

Various types of headaches are common in patients with pituitary adenomas. The adenoma may be the prime causative factor behind the headache or may serve to exacerbate a headache caused by other factors. Amongst the types of headaches experienced are both chronic and episodic migraine, and more uncommonly various unilateral headaches; primary stabbing headache,[31] short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)[32] - another type of stabbing headache characterized by short stabs of pain -, cluster headache,[33] and hemicrania continua (HS).[34]

Psychiatric[edit]

Various psychiatric manifestations have been associated with pituitary disorders including pituitary adenomas. Psychiatric symptoms such as depression, anxiety[35] apathy, emotional instability, easy irritability and hostility have been noted.[36]

Complications[edit]

Morphological facial changes caused by acromegaly; frontal bossing, enlarged nose, prognathism and maxillary widening with separation of teeth and unseen, enlargement of the tongue (macroglossia).
Cushing's disease may cause fatigue, weight gain, fatty deposits around the abdomen and lower back (truncal obesity) and face ("moon face"), stretch marks (striae) on the skin of the abdomen, thighs, breasts and arms, hypertension, glucose intolerance and various infections. In women it may cause excessive growth of facial hair (hirsutism) and in men erectile dysfunction. Psychiatric manifestations may include depression, anxiety, easy irritability and emotional instability. It may also result in various cognitive difficulties.
The diagnosis of CDI is based on the results of urine and blood tests, and a water deprivation test which tests the body's ability to concentrate urine. CDI is often treated with desmopressin acetate a synthetic vasopressin known as DDAVP administered via nasal spray.

Diagnosis and workup[edit]

Diagnosis of pituitary adenoma can be made, or at least suspected, by a constellation of related symptoms presented above.

Tumors which cause visual difficulty are likely to be a macroadenoma greater than 10 mm in diameter; tumors less than 10 mm are microadenoma.

The differential diagnosis includes pituitary tuberculoma, especially in developing countries and in immumocompromised patients.[43] The diagnosis is confirmed by testing hormone levels, and by radiographic imaging of the pituitary (for example, by CT scan or MRI).

Treatment[edit]

Treatment options depend on the type of tumor and on its size:

See also[edit]

References[edit]

  1. ^ a b c Ezzat, Shereen; Asa, Sylvia L.; Couldwell, William T.; Barr, Charles E.; Dodge, William E.; Vance, Mary Lee; McCutcheon, Ian E. (2004). "The prevalence of pituitary adenomas". Cancer 101 (3): 613–9. doi:10.1002/cncr.20412. PMID 15274075. 
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External links[edit]