The systematic name of this enzyme class is 3-sn-phosphatidate phosphohydrolase. Other names in common use include:
phosphatidic acid phosphatase (PAP),
acid phosphatidyl phosphatase,
phosphatidic acid phosphohydrolase,
phosphatidate phosphohydrolase, and
lipid phosphate phosphohydrolase (LPP).
There are several different genes that codify for phosphatidate phosphatases. They been classified in two groups (type I and type II) based on their cellular localization and substrate specificity.
Type I phosphatidate phosphatases are soluble enzymes that can associate to membranes. There are found mainly in the cytosol and the nucleus. Codified by a group of genes named Lipin they are substrate specific only to phosphatidate. There are speculated to be involved in the de novo synthesis of glycerolipids.
Type II phosphatidate phospatases are transmembrane enzymes found mainly in the plasma membrane. They can also dephosphorylate other substrates beside phosphatidate therefore are also known as lipid-phosphate phosphatase. Their main role is in lipid signaling and in phospholipid head-group remodeling.
Human genes that encode phosphatidate phosphatases include:
PPAP2A (LPP1) – phosphatidic acid phosphatase type 2A
PPAP2B (LPP3) – phosphatidic acid phosphatase type 2B
PPAP2C (LPP2) – phosphatidic acid phosphatase type 2C