Periostin

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Periostin, osteoblast specific factor
Identifiers
SymbolsPOSTN ; OSF-2; OSF2; PDLPOSTN; PN; periostin
External IDsOMIM608777 MGI1926321 HomoloGene4730 GeneCards: POSTN Gene
RNA expression pattern
PBB GE POSTN 210809 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1063150706
EnsemblENSG00000133110ENSMUSG00000027750
UniProtQ15063Q62009
RefSeq (mRNA)NM_001135934NM_001198765
RefSeq (protein)NP_001129406NP_001185694
Location (UCSC)Chr 13:
38.14 – 38.17 Mb
Chr 3:
54.36 – 54.39 Mb
PubMed search[1][2]
 
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Periostin, osteoblast specific factor
Identifiers
SymbolsPOSTN ; OSF-2; OSF2; PDLPOSTN; PN; periostin
External IDsOMIM608777 MGI1926321 HomoloGene4730 GeneCards: POSTN Gene
RNA expression pattern
PBB GE POSTN 210809 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1063150706
EnsemblENSG00000133110ENSMUSG00000027750
UniProtQ15063Q62009
RefSeq (mRNA)NM_001135934NM_001198765
RefSeq (protein)NP_001129406NP_001185694
Location (UCSC)Chr 13:
38.14 – 38.17 Mb
Chr 3:
54.36 – 54.39 Mb
PubMed search[1][2]

Periostin is a protein that in humans is encoded by the POSTN gene.[1][2] Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells.[3]

Clinical significance[edit]

In asthma[edit]

Periostin is associated with asthma, a fact that is exploited by the experimental asthma medication lebrikizumab.[4]

In cancer[edit]

Periostin over-expression was reported in several types of cancer, most frequently in the environment of tumor cells.[3][5] Recent evidence shows that periostin is a component of the extracellular matrix expressed by fibroblasts in normal tissues and stroma of primary tumor. The metastatic colony formation requires the induction of periostin in the foreign stroma by the infiltrating cancer cells. Periostin production is upregulated in lung fibroblasts by either TGF-β2 or TGF-β3, the latter being secreted by infiltrating cancer stem cells (in MMTV-PyMT mouse breast cancer model) [6]

Table: Periostin expression in various cancer cell lines.[7]

Cell lineOriginPOSTN/ACTB1
U2OSOsteosarcoma3.5±1.7
LB96Ewing Sarcoma0
LB23-1Rhabdomyosarcoma0.1±0.1
HeLaCervical cancer3.0±0.4
PA-1Ovarian teratocarcinoma1.4±0.1
LB37-1NSCLC2.8±0.6
LB85SCLC3.4±0.2
LB92SCLC0.6±0.2
LB1047Renal cell carcinoma0.8±0.2
BB64Renal cell carcinoma0.08±0.01
LB108Colorectal cancer0
MCF7Breast Cancer0
Hs578TBreast Cancer3693±86
Panc-1Pancreatic carcinoma0
Capan-1Pancreatic carcinoma0
Huh-7Hepatocarcinoma0.3±0.07
LB831Bladder carcinoma1748±74
MZGC3Stomach cancer0
A172Glioblastoma45±4
MZ2Melanoma2.3±0.7
LB39Melanoma0.5±0.03
LB2586-7Melanoma3.4±0.3
LB2201-3Melanoma4.2±0.4
A375Melanoma4.7±1.2

1 (cDNA POSTN/cDNA ACTB) × 104

References[edit]

  1. ^ Takeshita S, Kikuno R, Tezuka K, Amann E (Sep 1993). "Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I". Biochem J. 294. ( Pt 1): 271–8. PMC 1134594. PMID 8363580. 
  2. ^ "Entrez Gene: POSTN periostin, osteoblast specific factor". 
  3. ^ a b Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD (Sep 2002). "Periostin secreted by epithelial ovarian carcinoma is a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins and promotes cell motility". Cancer Res 62 (18): 5358–64. PMID 12235007. 
  4. ^ Corren J, Lemanske RF, Hanania NA, et al. (September 2011). Lebrikizumab treatment in adults with asthma 365 (12). pp. 1088–98. doi:10.1056/NEJMoa1106469. PMID 21812663. 
  5. ^ Contié S, Voorzanger-Rousselot N, Litvin J, et al. (2011). "Increased expression and serum levels of the stromal cell-secreted protein periostin in breast cancer bone metastases.". Int. J. Cancer 128 (2): 352–60. doi:10.1002/ijc.25591. PMID 20715172. 
  6. ^ Malanchi I, Santamaria-Martínez A, Susanto E, et al. (2011). "Interactions between cancer stem cells and their niche govern metastatic colonization". Nature 481 (7379): 85–9. doi:10.1038/nature10694. PMID 22158103. 
  7. ^ Tilman G, Mattiussi M, Brasseur F, van Baren N, Decottignies A. (2007). "Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.". Molecular Cancer 6 (80): 80. doi:10.1186/1476-4598-6-80. PMC 2222651. PMID 18086302. 

Further reading[edit]