Perindopril/indapamide

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Perindopril/indapamide
Combination of
PerindoprilACE inhibitor
IndapamideThiazide diuretic
Clinical data
Legal status
RoutesOral
Identifiers
ATC codeC09BA04
PubChemCID 9940214
ChemSpider8115834 YesY
 YesY (what is this?)  (verify)
 
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Perindopril/indapamide
Combination of
PerindoprilACE inhibitor
IndapamideThiazide diuretic
Clinical data
Legal status
RoutesOral
Identifiers
ATC codeC09BA04
PubChemCID 9940214
ChemSpider8115834 YesY
 YesY (what is this?)  (verify)

Perindopril/indapamide is a combination therapy for the treatment of Essential hypertension.

Form and Composition[edit]

Each scored tablet contains 2 mg of perindopril tert-butylamine salt and 0.625 mg of indapamide.

Indication[edit]

Essential hypertension.

Dosage and Administration[edit]

One tablet daily, preferably to be taken in the morning and before a meal.

Pharmacological Action[edit]

PRETERAX(also known as COVERAM in some countries now), a fixed combination of an ACE inhibitor and a chlorosulfamoyl diuretic, leads to additive synergy of the antihypertensive effects of the two constituents. Its pharmacological properties are derived from those of each of the components taken separately, in addition to those due to the additive synergistic action of the two constituents, when combined, on vascular endothelium, arteriolocapillary microcirculation, and the target organs of hypertension. Elderly patients: Normal dosage. Renal failure: Creatinine clearance (CrCl) >30 mL/min: no dosage modification. CrCl <30 ml/min: treatment contraindicated.

Contraindications[edit]

Absolute: Known allergy to perindopril, indapamide, or sulfonamides; history of Quincke's edema linked to previous ACE inhibitor therapy; severe renal failure; serious liver disorder; hyperkalemia; pregnancy; lactation. Relative: Combination therapy with lithium, potassium salts, potassium-sparing diuretics, and certain medicines which can cause heart rhythm disorders.

Side Effects[edit]

Asthenia, dizziness, headache, mood swings and/or sleep disturbances, cramps, hypotension, allergic reactions, skin rashes, gastrointestinal disorders, dry cough, erectile dysfunctions, dry mouth, risk of dehydration in the elderly and in patients suffering from heart failure, sexual dysfunctions; changes in blood test results may occur.

Warnings[edit]

Immunosuppressed patients. Hemodialysis: risk of anaphylactoid reaction during hemodialysis with polyacrylonitrile membranes. Liver impairment.

Precautions[edit]

Disorders of electrolyte balance, diabetes, gout, hypotension, or strict sodium-free diets, heart or renal failure, atherosclerosis, renal artery stenosis, elderly.

Drug Interactions[edit]

Not recommended: Combinations with lithium, potassium-sparing diuretics, potassium (salts), antiarrhythmic drugs which cause torsade de pointes, anesthetic drugs, cytostatic or immunosuppressive agents.