Partinico (Sicilian: Partinicu, Ancient Greek: Parthenikòn) is a town and comune in the province of Palermo, Sicily, southern Italy. It is located at 30 km from Palermo and 71 from Trapani.
- Church of San Giuseppe, housing 17th century paintings.
- Neo-Classicist Chiosco della Musica.
- Baroque fountain.
- Real Cantina Borbonica.
The paternal side of musician Frank Zappa's family came from the town. The Italian prime minister Orlando represented Partinico in the Italian Parliament from 1897 until 1925.
The local, family-run, anti-Mafia television station Telejato is based in Partinico.