Pantoprazole

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Pantoprazole
Pantoprazole.svg
Systematic (IUPAC) name
(RS)-6-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole
Clinical data
Trade namesProtonix
AHFS/Drugs.commonograph
MedlinePlusa601246
Licence dataUS FDA:link
Pregnancy cat.B3 (AU) B (US)
Legal status Prescription only
RoutesOral and intravenous
Pharmacokinetic data
Bioavailability77%
MetabolismHepatic (CYP3A4)
Half-life1 hour
ExcretionRenal
Identifiers
CAS number102625-70-7 YesY
ATC codeA02BC02
PubChemCID 4679
DrugBankDB00213
ChemSpider4517 YesY
UNIID8TST4O562 YesY
KEGGD05353 YesY
ChEBICHEBI:7915 YesY
ChEMBLCHEMBL1502 YesY
Chemical data
FormulaC16H15F2N3O4S 
Mol. mass383.371 g/mol
 YesY (what is this?)  (verify)
 
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Pantoprazole
Pantoprazole.svg
Systematic (IUPAC) name
(RS)-6-(Difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]-1H-benzo[d]imidazole
Clinical data
Trade namesProtonix
AHFS/Drugs.commonograph
MedlinePlusa601246
Licence dataUS FDA:link
Pregnancy cat.B3 (AU) B (US)
Legal status Prescription only
RoutesOral and intravenous
Pharmacokinetic data
Bioavailability77%
MetabolismHepatic (CYP3A4)
Half-life1 hour
ExcretionRenal
Identifiers
CAS number102625-70-7 YesY
ATC codeA02BC02
PubChemCID 4679
DrugBankDB00213
ChemSpider4517 YesY
UNIID8TST4O562 YesY
KEGGD05353 YesY
ChEBICHEBI:7915 YesY
ChEMBLCHEMBL1502 YesY
Chemical data
FormulaC16H15F2N3O4S 
Mol. mass383.371 g/mol
 YesY (what is this?)  (verify)

Pantoprazole (sold under various brand names including Somac, Tecta, Pantoloc, Dew-Pantadom, Controloc,Panprax, Pansiv, Protium,Prazolin, Protonix, Pantecta, Pantoheal, Pantpas, Ppi-40, and Neoppi) is a proton pump inhibitor drug that inhibits gastric acid secretion.

Use[edit]

Pantoprazole is used for short-term treatment of erosion and ulceration of the oesophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary.[citation needed] It can be used as a maintenance therapy for long term use after initial response is obtained.

This medication may affect the results of certain lab tests, such as drug screenings (pantoprazole can cause a false positive for THC, the psychoactive component of cannabis[1][2]). It has also been known to cause false positive for benzodiazepines.[citation needed]

Adverse effects[edit]

Antacid preparations such as pantoprazole work by suppressing the acid-mediated breakdown of proteins. This leads to an elevated risk of developing food and drug allergies due to undigested proteins passing into the gastrointestinal tract where sensitisation occurs. It is unclear whether this risk occurs with short-term or only long-term use.[3]

Common[edit]

Serious[edit]

Pharmacology[edit]

Wyeth pantoprazole 20mg.

Pantoprazole is metabolized in the liver by the cytochrome P450 system.[6] Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance. Pantoprazole is relatively free of drug interactions;[7] however, it may alter the absorption of other medications that depend on the amount of acid in the stomach, such as ketoconazole or digoxin. Generally inactive at acidic pH of stomach, thus it is usually given with a pro kinetic drug. Pantoprazole binds irreversibly to H+K+ATPase (proton pumps) and suppresses the secretion of acid. As it binds irreversibly to the pumps, new pumps have to be made before acid production can be resumed. The drug's plasma half-life is about 2 hours.[8]

Pharmacokinetics[edit]

Absorption

Distribution

Metabolism

Excretion

Elimination Half Life

Availability[edit]

Pantoprazole was developed by Altana (owned by Nycomed) and was licensed in the USA to Wyeth (which was taken over by Pfizer) and is currently marketed under the brand name Protonix by Wyeth-Ayerst Laboratories, Pansiv by Saharsh Biologicals, Pantec by Concept Pharmaceuticals, Somac by Pfizer, API by Vanguard Therapeutics, Astropan by Astron Lifesciences, Fenix by Bosnalijek, Pantecta by Novartis, Pantoloc, Controloc or Somac by Nycomed, Tecta by Nycomed in Canada, Protium in the UK, Inipomp by Sanofi or Eupantol by Nycomed in France, Pantozol by Nycomed in Germany, Pantodac, Perizole by Obsurge Biotech and Pansped in India, Zurcazol in Greece, Protonex by Abdi İbrahim in Turkey, Pantup in Ireland, Pantomed in Belgium, TopZole in South Africa, Nolpaza and Controloc in Romania and as UXL-D in India, Pantid by Opsonin in Bangladesh. Pantid is the first brand in the world which is providing in double Alu-Alu sachet packaging to prevent its degradation from moisture & light.The generic pantoprazole sodium is available in the U.S. from Kremers Urban, Teva, and Torrent Pharma. It is available by prescription in delayed-release tablets. It is also available for intravenous use.

On 24 December 2007, Teva Pharmaceutical released an AB-rated generic alternative to Protonix.[9] This was followed by generic equivalents from Sun Pharma and Kudco Pharma. Wyeth sued all three for patent infringement and launched its own generic version of Protonix with Nycomed.[10][11]

On October 18, 2010 the U.S. Food and Drug Administration (FDA) accepted the filing of an ANDA for a delayed release generic version of Protonix by Canadian company IntelliPharmaCeutics.[12] The combination of domperidone 10 mg and pantoprazole 40 mg is available in India under the brand name Pantazone, Pantop-D, Rantop-D. Also, Indian pharmaceutical company Sun Pharmaceutical produces pantoprazole under the brand name Pantasan, which is available in Russia and Belarus. In Bangladesh Apex Pharma Limited markets pantoprazole under the brand name Pantrol. It is also available under the brand name Prazolin marketed by Rephco Pharmaceuticals Limited. It is also marketed by Chemist Laboratories Ltd. under the brand name Pantochem.

References[edit]

  1. ^ Protonix package insert 12/07
  2. ^ "What causes false positives in marijuana drug testing?". LiveStrong. 
  3. ^ Pali-Schöll I, Jensen-Jarolim E (April 2011). "Anti-acid medication as a risk factor for food allergy". Allergy 66 (4): 469–77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928. 
  4. ^ [Dr. John Cooke, chair of Methodist Hospital's cardiovascular services] [Houston Chronicle Health Zone dated Thursday, July 11, 2013 chron.com/refluxmeds] (Journal: Circulation)
  5. ^ [Dr. John Cooke, chair of Methodist Hospital's cardiovascular services] [Houston Chronicle Health Zone dated Thursday, July 11, 2013 chron.com/refluxmeds] (Journal: Circulation)
  6. ^ Meyer, U A (1996). "Metabolic interactions of the proton-pump inhibitors lansoprazole, omeprazole and pantoprazole with other drugs". European journal of gastroenterology & hepatology 8 (Suppl 1): S21–25. doi:10.1097/00042737-199610001-00005. 
  7. ^ Steinijans, V. W.; Huber, R.; Hartmann, M.; Zech, K.; Bliesath, H.; Wurst, W.; Radtke, H. W. (1996). "Lack of pantoprazole drug interactions in man: An updated review". International Journal of Clinical Pharmacology and Therapeutics 34 (6): 243–262. PMID 8793611. 
  8. ^ Sachs G, Shin JM, Hunt R (December 2010). "Novel approaches to inhibition of gastric acid secretion". Curr Gastroenterol Rep 12 (6): 437–47. doi:10.1007/s11894-010-0149-5. PMC 2974194. PMID 20924727. 
  9. ^ Teva Announces Launch Of Generic Protonix Tablets
  10. ^ Rubenstein, Sarah (29 January 2008). "Wyeth Plans Generic Protonix; Litigation With Teva to Continue". The Wall Street Journal. p. D9. Retrieved 25 October 2009. 
  11. ^ "Nycomed and Wyeth announce launch of an own generic version of PROTONIX - lawsuit to defend patent continues". Retrieved 25 October 2009. [dead link]
  12. ^ IntelliPharmaCeutics Press Release

External links[edit]