Oxycodone/paracetamol

From Wikipedia, the free encyclopedia - View original article

Oxycodone/paracetamol
Combination of
OxycodoneOpioid analgesic
ParacetamolAnilide analgesic
Clinical data
Trade namesPercocet
AHFS/Drugs.comentry
Licence dataUS FDA:link
Pregnancy cat.C
Legal statusSchedule II (US)
RoutesOral
Identifiers
CAS number330988-72-2 YesY
ATC code ?
ChemSpider4881971 YesY
 YesY (what is this?)  (verify)
 
Jump to: navigation, search
Oxycodone/paracetamol
Combination of
OxycodoneOpioid analgesic
ParacetamolAnilide analgesic
Clinical data
Trade namesPercocet
AHFS/Drugs.comentry
Licence dataUS FDA:link
Pregnancy cat.C
Legal statusSchedule II (US)
RoutesOral
Identifiers
CAS number330988-72-2 YesY
ATC code ?
ChemSpider4881971 YesY
 YesY (what is this?)  (verify)

The combination oxycodone/paracetamol (North American trade name Percocet) is a narcotic pain reliever used to treat moderate to severe acute (short-term) pain, marketed by Endo Pharmaceuticals.[1] It is regulated as a schedule 2 narcotic by the Drug Enforcement Agency (DEA)

Contents

History

The U.S. Food and Drug Administration first approved Percocet in 1976, under application ANDA 085106.[2]

Formulation

As of March 2006, Endo Pharmaceuticals produces Percocet in following dosages.[3] Percocet tablets are available in six combinations of oxycodone hydrochloride and acetaminophen, with different appearances and maximum daily doses:[3]

Oxycodone Hydrochloride (mg)Acetaminophen (mg)Tablet ColorTablet ShapeMaximum Daily Dose
2.5325pinkoval12 tablets
5325whiteround12 tablets
7.5325peachoval8 tablets
7.5500peachcapsule-shaped8 tablets
10.0325whiteoblong6 tablets
10.0650yellowoval6 tablets

For the 2.5 mg Oxycodone HCl tablet, the usual dose is 1–2 tablets every six hours as needed for pain; for the other tablets, the usual dose is 1 tablet every six hours as needed for pain.[3]

Use in pain management

This medicine, in recent years, has gained favor among the medical community due to its effectiveness and a lower addiction rate than morphine. It is very useful for patients who are experiencing acute severe pain that is neither chronic nor breakthrough.[citation needed]

Implicated in deaths

On June 30, 2009, an FDA advisory panel recommended that Percocet, Vicodin, and every other combination of acetaminophen with narcotic analgesics[4] be limited in their sales because of their contributions to an alleged 400 acetaminophen related deaths in the United States each year, that were attributed to acetaminophen overdose and associated liver damage.[5]

In December 2009, the Canadian Medical Association Journal reported a study finding a fivefold increase in oxycodone-related deaths in Ontario (mostly accidental) between 1991 and 2007 that led to a doubling of all opioid-related Ontario deaths over the same period.[6][7][8]

See also

References

  1. ^ http://www.endo.com/pdf/products/Percocet_pack_insert_2.pdf
  2. ^ "Drugs@FDA. FDA approved drug products (searchable database)". U.S. Food and Drug Administration, Center for Drug Evaluation and Research. http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm. Retrieved 2009-03-30. 
  3. ^ a b c "Percocet oxycodone and acetaminophen tablets USP". Endo Pharmaceuticals. 2006 November. http://www.endo.com/pdf/products/Percocet_pack_insert_4.pdf. Retrieved 2009-03-30. 
  4. ^ http://www.webmd.com/pain-management/news/20090701/fda-may-restrict-acetaminophen
  5. ^ Harris, Gardiner (2009-07-01). "Ban Is Advised on 2 Top Pills for Pain Relief". The New York Times. http://www.nytimes.com/2009/07/01/health/01fda.html?em. Retrieved 2010-05-22. 
  6. ^ Irfan A. Dhalla, Muhammad M. Mamdani, Marco L.A. Sivilotti, Alex Kopp, Omar Qureshi, David N. Juurlink. Prescribing of opioid analgesics and related mortality before and after the introduction of long-acting oxycodone. Canadian Medical Association Journal, 2009; 181 (12): 891 DOI: 10.1503/cmaj.090784
  7. ^ Benedikt Fischer, Jürgen Rehm. Deaths related to the use of prescription opioids. Canadian Medical Association Journal, 2009; Fischer, B.; Rehm, J. (2009). "Deaths related to the use of prescription opioids". Canadian Medical Association Journal 181 (12): 881–882. doi:10.1503/cmaj.091791. PMC 2789122. PMID 19969577. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2789122/.  edit
  8. ^ Canadian Medical Association Journal (2009, December 7). Deaths from opioid use have doubled; five-fold increase in oxycodone deaths. ScienceDaily. Retrieved May 31, 2012, from http://www.sciencedaily.com/releases/2009/12/091207123105.htm

External links