Nucleus pulposus

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Nucleus pulposus
Cervical vertebra english.png
Cervical vertebra with intervertebral disc. (Nucleus pulposus labeled at center right, and is visible at center in light blue.)
Disc Herniation.JPG
Stages of Spinal Disc Herniation
LatinNucleus pulposus
Gray'ssubject #17 82
Precursornotochord
 
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Nucleus pulposus
Cervical vertebra english.png
Cervical vertebra with intervertebral disc. (Nucleus pulposus labeled at center right, and is visible at center in light blue.)
Disc Herniation.JPG
Stages of Spinal Disc Herniation
LatinNucleus pulposus
Gray'ssubject #17 82
Precursornotochord

Nucleus pulposus is the jelly-like substance in the middle of the spinal disc. It is the remnant of the notochord.[1] It functions to distribute hydraulic pressure in all directions within each disc under compressive loads. The nucleus pulposus consists of chondrocyte-like cells, collagen fibrils, and proteoglycan aggrecans that aggregate through hyaluronic chains. Attached to each aggrecan molecule are the glycosaminoglycan (GAG) chains of chondroitin sulfate and keratan sulfate.[2] Aggrecan is negatively charged and hydrophilic. This property allows it to draw water into the Nucleus Pulposus.

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References

[3]

  1. ^ McCann, Matthew; Owen J. Tamplin, Janet Rossant and Cheryle A. Séguin (25). "Tracing notochord-derived cells using a Noto-cre mouse: implications for intervertebral disc developmen". Disease Models & Mechanisms. doi:10.1242/dmm.008128. http://dmm.biologists.org/content/early/2011/11/01/dmm.008128.long.
  2. ^ See Figure 1 in US patent application 2007/0003525.
  3. ^ Link to referenced patent application.

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