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Negative-pressure wound therapy (NPWT) is a therapeutic technique using a vacuum dressing to promote healing in acute or chronic wounds and enhance healing of first and second degree burns. The therapy involves the controlled application of sub-atmospheric pressure to the local wound environment, using a sealed wound dressing connected to a vacuum pump. The use of this technique in wound management increased dramatically over the 1990s and 2000s and a large number of studies have been published examining NPWT. NPWT appears to be useful for diabetic ulcers and management of the open abdomen (laparotomy)  but further research is required for other wound types.
NPWT promotes wound healing by applying a vacuum through a special sealed dressing. The continued vacuum draws out fluid from the wound and increases blood flow to the area.[unreliable medical source?] The vacuum may be applied continuously or intermittently, depending on the type of wound being treated and the clinical objectives. Typically, the dressing is changed two to three times per week. The dressings used for the technique include open-cell foam dressings and gauze, sealed with an occlusive dressing intended to contain the vacuum at the wound site.[unreliable medical source?] Where NPWT devices allow delivery of fluids, such as saline or antibiotics to irrigate the wound,[unreliable medical source?][unreliable medical source?] intermittent removal of used fluid supports the cleaning and drainage of the wound bed.
In 1995, Kinetic Concepts was the first company to have a NPWT product cleared by the US Food and Drug Administration. Following increased use of the technique by hospitals in the US, the procedure was approved for reimbursement by the Centers for Medicare and Medicaid Services in 2001.[unreliable medical source?]
General technique for NPWT is as follows: a dressing or filler material is fitted to the contours of a wound (which is covered with a non-adherent dressing film) and the overlying foam is then sealed with a transparent film. A drainage tube is connected to the dressing through an opening of the transparent film. A vacuum tube is connected through an opening in the film drape to a canister on the side of a vacuum pump. or vacuum source, turning an open wound into a controlled, closed wound while removing excess fluid from the wound bed to enhance circulation and remove wound fluids. This creates a moist healing environment and reduces edema. The technique is usually used with chronic wounds or wounds that are expected to present difficulties while healing (such as those associated with diabetes).
With all three techniques, once the dressing is sealed the vacuum pump can be set to deliver continuous or intermittent pressures, with levels of pressure depending on the device used, varying between −125 and −75 mmHg depending on the material used and patient tolerance. Pressure can be applied constantly or intermittently.
The dressing type used depends on the type of wound, clinical objectives and patient. For pain sensitive patients with shallow or irregular wounds, wounds with undermining or explored tracts or tunnels, gauze may be used, while foam may be cut easily to fit a patient’s wound that has a regular contour and perform better when aggressive granulation formation and wound contraction is the desired goal.
A 2007 Cochrane Review stated that the evidence comparing NPWT to alternative care was flawed and required more study, but the evidence did support improved healing and called for more, better quality research to be conducted. A 2010 systematic review found "consistent evidence of the benefit of NPWT" in the treatment of diabetic ulcers of the feet. Results for bedsores was "conflicting" and research on "mixed wounds" was of poor quality, but promising. The review did not find evidence of increased significant complications. The review concluded "There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated."