Myoglobinuria

From Wikipedia, the free encyclopedia - View original article

Myoglobinuria
Classification and external resources

Urine from a person with rhabdomyolysis showing the characteristic brown discoloration as a result of myoglobinuria
ICD-10R82.1
ICD-9791.3
DiseasesDB23059
eMedicineped/1535
MeSHD009212
 
Jump to: navigation, search
Myoglobinuria
Classification and external resources

Urine from a person with rhabdomyolysis showing the characteristic brown discoloration as a result of myoglobinuria
ICD-10R82.1
ICD-9791.3
DiseasesDB23059
eMedicineped/1535
MeSHD009212
Model of helical domains in myoglobin.

Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction. Myoglobin is present in muscle cells as a reserve of oxygen.

Contents

Causes

Trauma, vascular problems, venoms, malignant hyperthermia, certain drugs and other situations can destroy or damage the muscle, releasing myoglobin to the circulation and thus to the kidneys.

Under ideal situations myoglobin will be filtered and excreted with the urine, but if too much myoglobin is released into the circulation or in case of renal problems, it can occlude the renal filtration system leading to acute tubular necrosis and acute renal insufficiency.

Other causes of myoglobinuria include:

Diagnosis

After centrifuging, the serum of myoglobinuria is clear, where the serum of hemoglobinuria after centrifuge is pink.[citation needed]

External links

References

  1. ^ Toscano A, Musumeci O (October 2007). "Tarui disease and distal glycogenoses: clinical and genetic update". Acta Myol 26 (2): 105–7. PMC 2949577. PMID 18421897. //www.ncbi.nlm.nih.gov/pmc/articles/PMC2949577/.