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Nurses are traditionally and predominantly female due to the long history of discrimination against men; in 2008, of the 3,063,163 licensed registered nurses in the United States only 6.6% of were men. Men also make up only 13% of all new nursing students. A number of possible reasons exist for why nursing is largely a female profession and why relatively few men seek to enter it.
During plagues that swept through Europe, male nurses were primary caregivers. In the 3rd century, men in the Parabolani created a hospital and provided nursing care. It has been asserted, without proof, that the brotherhood was first organized during the great plague in Alexandrian episcopate of Dionysius the Great (second half of 3rd century). They received their name from the fact that they risked their lives (παραβάλλεσθαι τὴν ζωήν, paraballesthai tēn zōēn) in exposing themselves to contagious diseases. In addition, they constituted a bodyguard for the bishop. Their number was never large. The Codex Theodosianus of 416 (xvi, 2, 42) restricted the enrollment in Alexandria to 500.
There were numerous other nurses that were male throughout the Middle Ages. St. Benedict started the Benedictine nursing order. The Alexian Brothers, in the 14th century, provided nursing care for the victims of the Black Death. These two organizations are still in existence today.
Military, religious, and lay orders of men continued to provide nursing care throughout the Middle Ages. Some of the most famous of these were the Knights Hospitalers, the Teutonic Knights, the Tertiaries, the Order of Saint Lazarus, the Order of the Holy Spirit, and the Hospital Brothers of St. Anthony.
Nursing schools for men were uncommon in the United States during the 1900's. Men served as nurses during times of war but by WWI men were expected to fight in the war and the nursing duties were reserved for female nurses. This tradition continued and men were no longer allowed to serve as nurses in both the military and civilian practices. By 1930 the discrimination of men resulted in men constituting fewer than 1% of RNs in the United States." Men were not allowed into the majority of Nursing Colleges until a Supreme Court Ruling in 1982 brought an end to the discrimination. By the 1970's, after decades of discrimination against men, the American Nurses Association finally relented to the pressure and allowed men to join. Gender shaming tactics are used frequently within the profession of nursing, resulting in few men feeling comfortable to pursue a career that is considered by some a privilege reserved for women.
In the past, men usually became nurses involuntarily "on to spot" in the midst of war, often religious wars, in an effort to save their fellow soldiers' lives. War was not the realm of women. This was the case until Florence Nightingale was allowed on the battlefield to minister to soldiers.
The American Assembly For Men in Nursing was founded in 1971, in response to the denial of male nurses into the American Nurses Association. The purpose of AAMN is to provide a safe framework, free of discrimination and vilification, for nurses as a group to meet, discuss, and influence factors which affect men as nurses. The main factors that effect men as nurses continue to be the resentment by some that men have taken a privilege that was once reserved only for women. 
In Mississippi University for Women v. Hogan, 458 U.S. 718 (1982), the U.S. Supreme Court ruled 5-4 that Mississippi University for Women's single sex admissions policy for its nursing school violated the Fourteenth Amendment's equal protection clause. Justice Sandra Day O'Connor wrote the landmark opinion.
In the 1980-1990’s, the end of the gender discrimination against men brought many men into the profession." 
More men are joining women by entering the nursing profession. "Study after study demonstrates that men come to the nursing profession for the same reasons women do. They want to care for sick and injured people, they want a challenging profession, and they want reasonable job security with good wages".
As many Western nations are facing a shortage of nurses, many governments and nursing schools are actively recruiting more men as nurses. In example, when the University of Pittsburgh increased its admission requirements for its nursing program, the number of male applicants spiked significantly.
Spokesman Thomas Holly stated on behalf of all male nurses in University of Limerick that they are currently celebrated in all hospitals throughout the Mid-West of Ireland and female nurses continually look forward to seeing male nurses arrive on wards.