Mebane straddles the Research Triangle and the Piedmont Triad areas of North Carolina. However, a majority of the phone numbers listed for the city are in the 919/984 area code, whereas the rest of Alamance County is situated in the 336 area code (originally 910). When the decision was made to split the Triad and Triangle into separate area codes, it was decided that Mebane would stay in 919 to keep the numbers on the Orange County portion uniform with the rest of the city.
The public schools in Mebane include Eastern Alamance High School, Hawfields Middle School, Woodlawn Middle School, Audrey W. Garrett Elementary School, South Mebane Elementary School, and E. M. Yoder Elementary School. Students in the area are served by part of the Alamance-Burlington School System (which was created by a merger between the Alamance County School System and the Burlington City School System in 1996) and the Orange County Schools.