Slow growth, painlessness (as the ulcer is usually not associated with nerve tissue), and absence of lymphatic spread due to local destruction of lymphatic channels.
Characteristics[edit source | edit]
Histologically, the tumour is a well-differentiated squamous cell carcinoma. This carcinoma is aggressive in nature, spreads locally and is associated with a poor prognosis. 40% occur on the lower limb and the malignant change is usually painless. This malignant change of the wound happens a long time after initial trauma, usually 10–25 years later.its edge is everted and not always raised
Diagnosis[edit source | edit]
Wedge biopsy is the favored method of diagnosis. Tissue specimens obtained should be taken from both the centre and margin of lesion, as the central ulcerated deposits may be necrotic.
Treatment[edit source | edit]
Treatment is usually surgical, with a wide excision of the lesion; typically a 1 cm margin all around is required. Radiation therapy is also a good alternative in most cases.