MRAS

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Muscle RAS oncogene homolog
Protein MRAS PDB 1x1r.png
PDB rendering based on 1x1r.
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsMRAS ; M-RAs; R-RAS3; RRAS3
External IDsOMIM608435 MGI1100856 HomoloGene7424 GeneCards: MRAS Gene
RNA expression pattern
PBB GE MRAS 206538 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2280817532
EnsemblENSG00000158186ENSMUSG00000032470
UniProtO14807O08989
RefSeq (mRNA)NM_001085049NM_008624
RefSeq (protein)NP_001078518NP_032650
Location (UCSC)Chr 3:
138.07 – 138.12 Mb
Chr 9:
99.39 – 99.44 Mb
PubMed search[1][2]
 
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Muscle RAS oncogene homolog
Protein MRAS PDB 1x1r.png
PDB rendering based on 1x1r.
Available structures
PDBOrtholog search: PDBe, RCSB
Identifiers
SymbolsMRAS ; M-RAs; R-RAS3; RRAS3
External IDsOMIM608435 MGI1100856 HomoloGene7424 GeneCards: MRAS Gene
RNA expression pattern
PBB GE MRAS 206538 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2280817532
EnsemblENSG00000158186ENSMUSG00000032470
UniProtO14807O08989
RefSeq (mRNA)NM_001085049NM_008624
RefSeq (protein)NP_001078518NP_032650
Location (UCSC)Chr 3:
138.07 – 138.12 Mb
Chr 9:
99.39 – 99.44 Mb
PubMed search[1][2]

Ras-related protein M-Ras is a protein that in humans is encoded by the MRAS gene.[1][2][3]

Members of the RAS superfamily of GTP-binding proteins, which includes MRAS, are membrane-anchored, intracellular signal transducers responsible for a variety of normal cellular functions. They are oncogenically activated in a significant fraction of tumors.[supplied by OMIM][3]

Interactions[edit]

MRAS has been shown to interact with RASSF5[4] and RALGDS.[1][5]

References[edit]

  1. ^ a b Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (Jan 1998). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994. 
  2. ^ Quilliam LA, Castro AF, Rogers-Graham KS, Martin CB, Der CJ, Bi C (Sep 1999). "M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1, and p120 Ras GTPase-activating protein, interacts with the putative Ras effector AF6". J Biol Chem 274 (34): 23850–7. doi:10.1074/jbc.274.34.23850. PMID 10446149. 
  3. ^ a b "Entrez Gene: MRAS muscle RAS oncogene homolog". 
  4. ^ Ortiz-Vega, Sara; Khokhlatchev Andrei; Nedwidek Maria; Zhang Xian-feng; Dammann Reinhard; Pfeifer Gerd P; Avruch Joseph (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene (England) 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. ISSN 0950-9232. PMID 11857081. 
  5. ^ Ehrhardt, G R; Leslie K B; Lee F; Wieler J S; Schrader J W (Oct 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood (UNITED STATES) 94 (7): 2433–44. ISSN 0006-4971. PMID 10498616. 

Further reading[edit]