MARK4

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MAP/microtubule affinity-regulating kinase 4
Identifiers
SymbolsMARK4 ; MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D
External IDsOMIM606495 MGI1920955 HomoloGene57146 ChEMBL: 5754 GeneCards: MARK4 Gene
EC number2.7.11.1
RNA expression pattern
PBB GE MARK4 221560 at tn.png
PBB GE MARK4 55065 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez57787232944
EnsemblENSG00000007047ENSMUSG00000030397
UniProtQ96L34Q8CIP4
RefSeq (mRNA)NM_001199867NM_172279
RefSeq (protein)NP_001186796NP_758483
Location (UCSC)Chr 19:
45.58 – 45.81 Mb
Chr 7:
19.43 – 19.46 Mb
PubMed search[1][2]
 
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MAP/microtubule affinity-regulating kinase 4
Identifiers
SymbolsMARK4 ; MARK4L; MARK4S; MARKL1; MARKL1L; PAR-1D
External IDsOMIM606495 MGI1920955 HomoloGene57146 ChEMBL: 5754 GeneCards: MARK4 Gene
EC number2.7.11.1
RNA expression pattern
PBB GE MARK4 221560 at tn.png
PBB GE MARK4 55065 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez57787232944
EnsemblENSG00000007047ENSMUSG00000030397
UniProtQ96L34Q8CIP4
RefSeq (mRNA)NM_001199867NM_172279
RefSeq (protein)NP_001186796NP_758483
Location (UCSC)Chr 19:
45.58 – 45.81 Mb
Chr 7:
19.43 – 19.46 Mb
PubMed search[1][2]

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene.[1][2][3]


Interactions[edit]

MARK4 has been shown to interact with USP9X[4] and Ubiquitin C.[4]

References[edit]

  1. ^ Kato T, Satoh S, Okabe H, Kitahara O, Ono K, Kihara C, Tanaka T, Tsunoda T, Yamaoka Y, Nakamura Y, Furukawa Y (Apr 2001). "Isolation of a novel human gene, MARKL1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis". Neoplasia 3 (1): 4–9. doi:10.1038/sj/neo/7900132. PMC 1505019. PMID 11326310. 
  2. ^ Drewes G, Ebneth A, Preuss U, Mandelkow EM, Mandelkow E (May 1997). "MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption". Cell 89 (2): 297–308. doi:10.1016/S0092-8674(00)80208-1. PMID 9108484. 
  3. ^ "Entrez Gene: MARK4 MAP/microtubule affinity-regulating kinase 4". 
  4. ^ a b Al-Hakim, Abdallah K; Zagorska Anna; Chapman Louise; Deak Maria; Peggie Mark; Alessi Dario R (Apr 2008). "Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains". Biochem. J. (England) 411 (2): 249–60. doi:10.1042/BJ20080067. PMID 18254724. 

Further reading[edit]

  • Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Beghini A, Magnani I, Roversi G, et al. (2003). "The neural progenitor-restricted isoform of the MARK4 gene in 19q13.2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines.". Oncogene 22 (17): 2581–91. doi:10.1038/sj.onc.1206336. PMID 12735302. 
  • Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945. 
  • Brajenovic M, Joberty G, Küster B, et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network.". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Schneider A, Laage R, von Ahsen O, et al. (2004). "Identification of regulated genes during permanent focal cerebral ischaemia: characterization of the protein kinase 9b5/MARKL1/MARK4.". J. Neurochem. 88 (5): 1114–26. doi:10.1046/j.1471-4159.2003.02228.x. PMID 15009667. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Wissing J, Jänsch L, Nimtz M, et al. (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.". Mol. Cell Proteomics 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.