Losartan/hydrochlorothiazide

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Losartan/hydrochlorothiazide
Combination of
LosartanAngiotensin II receptor antagonist
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesAnzaplus, Cozaar comp, Hyzaar, Ocsaar Plus
Pregnancy cat.D (US)
Legal status Prescription only
RoutesOral
Identifiers
ATC codeC09DA01
PubChemCID 24783652
KEGGD07895
 
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Losartan/hydrochlorothiazide
Combination of
LosartanAngiotensin II receptor antagonist
HydrochlorothiazideThiazide diuretic
Clinical data
Trade namesAnzaplus, Cozaar comp, Hyzaar, Ocsaar Plus
Pregnancy cat.D (US)
Legal status Prescription only
RoutesOral
Identifiers
ATC codeC09DA01
PubChemCID 24783652
KEGGD07895

Losartan/hydrochlorothiazide is a combination drug used as an antihypertensive, consisting of losartan (an angiotensin II receptor antagonist) and hydrochlorothiazide (a diuretic).

The losartan/hydrochlorothiazide combination preparation is marketed by Merck under the trade name Hyzaar and by Xeno Pharmaceuticals under the name Anzaplus. Merck, Sharp & Dohme market it as Ocsaar Plus in Israel. It is marketed as Cozaar comp in Sweden.

In 2010, the patent for the combination expired, and a number of pharmaceutical companies promptly filed and received approval to sell the generic losartan, with and without hydrochlorothiazide, in the United States. [1]

Dosage

The recommended dosage of losartan-hydrochlorothiazide for people with high blood pressure (hypertension) will vary between losartan-hydrochlorothiazide 50 mg/12.5 mg and losartan-hydrochlorothiazide 100 mg/25 mg once a day. Based on the initial blood pressure response and/or losartan-hydrochlorothiazide side effects, the dosage may be increased or decreased. With each change in dosage, it may take up to a month to see the full effects of losartan-hydrochlorothiazide on lowering blood pressure.

References