In July 1993, she became an adult actress, but quit in 1997 due to an AIDS scare. She spent several years touring as a feature dancer at strip clubs around the country, before returning to the adult industry as an agent, and later again as a performer. Her first "comeback" movie was released on February 16, 2006.
On December 15, 2014, Ann announced her retirement from performing in adult films on Facebook.
Lisa Ann as Sarah Palin at the AVN Expo, Las Vegas, Nevada on January 8, 2010
Sarah Palin impersonation
On October 2, 2008, Lisa Ann was confirmed to star in Who's Nailin' Paylin? parodying 2008 Republican Vice Presidential candidate Sarah Palin, as "Serra Paylin". The movie, produced by Larry Flynt's Hustler Video, portrays Lisa Ann in sex scenes with other female porn stars parodying well-known female political figures, such as Hillary Clinton (played by veteran porn star Nina Hartley) and Condoleezza Rice (played by Jada Fire). The film was released on November 4, 2008, that year's election day. On October 31, 2008 Hustler announced that Lisa Ann was going to star in Obama is Nailin' Paylin, a scene that continued the adventures of Lisa as Sarah Paylin except this time Barack Obama would be lampooned as well. The scene is only available through their Hustler members website and on the Blu-ray release of the movie. It is not available on the DVD release. This "bonus scene" was released on election eve November 3, 2008. On August 26, 2009, Hustler released Letterman is Nailin Palin. Ann reprised her role as Palin in the music video for the song "We Made You" by Eminem. These appearances revived her on-screen career.
In August 2013, she launched her own production company, Lisa Ann Productions, and signed a distribution deal with Jules Jordan Video. Her directorial debut for the company, MILF Revolution, was released on August 5, 2013.MILF Revolution won the 2014 AVN Award for "Best MILF Release".
Her talent agency, Clear Talent Management, formed in November 2006, was later renamed Lisa Ann's Talent Management and merged with Adam Glasser's Lighthouse Agency in 2007 and eventually closed in July 2010.
In December 2009, it was announced that Lisa Ann had signed on to be the spokeswoman for RealTouch, a mechanised artificial vagina produced by AEBN. She later had her own genitalia molded for Fleshlight in 2011.
Lisa Ann also hosts a radio show called Lisa Ann Does Fantasy on Sirius/XM Fantasy Sports Radio. She states about the show, "I’m getting to go to a ton of games; I get to meet athletes; I get to go to training camps. … And it’s gotten me viewed on a different level, which is pretty cool." With regard to her appearances as men's clubs she says, "I’ve had guys buy [lap] dances just to get me to set their line-up."
In August 2014, Lisa Ann reached out to fellow porn actress Belle Knox, also known as the "Duke [University] porn star". Through her agent, who also represents Knox, she wanted to see "How’s she doing?". Lisa Ann has been mentoring an average of 10 to 15 girls since 2005. In an interview conducted by XBIZ Lisa Ann said she could sympathize with the media attention that Knox had faced. She experienced a similar one in 2008 when she played former vice presidential candidate, Sarah Palin. "I understand that being a new girl in the business can be a very lonely place... She’s already out on the road feature dancing, already has a million opportunities and I feel like if that all happened to me, if 'Palin' had happened to me at 19, I don’t know how I would’ve managed it," stated Lisa Ann. "So I reached out to her and we started just a little bit of mentoring by text, by phone, by Skype. And I enjoyed the bond when we talked."
Lisa Ann was ranked fifth on Complex Magazine's list of "The Top 100 Hottest Porn Stars (Right Now)" in 2011. She was also placed on CNBC's yearly list "The Dirty Dozen: Porn's Most Popular Stars" in 2011, 2012, and 2014. In April 2013, New York Post reported that she was "the most popular female porn star" according to data provided by Pornhub.
In October 2014, speculation was raised as to whether Lisa Ann and 18-year old Notre Dame football player Justin Brent were dating when the two appeared at a game together. After their appearance at Madison Square Garden, personal photos of the two in bed together were then released online.
Lisa Ann attending the XRCO Awards on April 16, 2009. Lisa Ann has won numerous awards within the adult entertainment industry, and is a member of the AVN, XRCO, Legends of Erotica and Urban X Halls of Fame.