Liraglutide

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Liraglutide (NN2211), marketed under the brand name Victoza, is a long-acting glucagon-like peptide-1 agonist (GLP-1 agonist) developed by Novo Nordisk for the treatment of type 2 diabetes. The product was approved by the European Medicines Agency (EMA) on July 3, 2009, and by the U.S. Food and Drug Administration (FDA) on January 25, 2010.[1][2][3][4][5]

Liraglutide is marketed under the brandname Victoza in the U.S., India, Canada, Europe and Japan. It has been launched in Germany, Denmark, the Netherlands, the United Kingdom, Ireland, Sweden, Japan, Canada, the United States, France, Malaysia and Singapore.

Phase I trials of an oral variant of Victoza (NN9924) started in 2010.[6]

Pharmacodynamics[edit]

Studies to date suggest liraglutide improves control of blood glucose.[7]

It reduces meal-related hyperglycemia (for 12 hours after administration) by increasing insulin secretion, delaying gastric emptying, and suppressing prandial glucagon secretion.

Liraglutide is an acylated human glucagon-like peptide-1 (GLP-1) agonist, with a 97% amino acid sequence identity to endogenous human GLP-1(7-37). GLP-1(7-37) represents less than 20% of total circulating endogenous GLP-1. Like GLP-1(7-37), liraglutide activates the GLP-1 receptor, a membrane-bound cell-surface receptor coupled to adenylyl cyclase by the stimulatory G-protein, Gs, in pancreatic beta cells. Liraglutide increases intracellular cyclic AMP (cAMP), leading to insulin release in the presence of elevated glucose concentrations. This insulin secretion subsides as blood glucose concentrations decrease and approach euglycemia. Liraglutide also decreases glucagon secretion in a glucose-dependent manner. The mechanism of blood glucose lowering also involves a delay in gastric emptying. GLP-1(7-37) has a half-life of 1.5–2 minutes due to degradation by the ubiquitous endogenous enzymes, dipeptidyl peptidase IV (DPP-IV) and neutral endopeptidases (NEP). Unlike native GLP-1, liraglutide is stable against metabolic degradation by both peptidases and has a plasma half-life of 13 hours after subcutaneous administration. The pharmacokinetic profile of liraglutide, which makes it suitable for once daily administration, is a result of self-association that delays absorption, plasma protein binding and stability against metabolic degradation by DPP-IV and NEP.[8]

Liraglutide may have advantages over current therapies:

Pharmacokinetics[edit]

Liraglutide is a once-daily GLP-1 derivative for the treatment of type 2 diabetes. GLP-1, in its natural form, is short-lived in the body (the half-life after intramuscular injection is approximately half an hour), so it is not very useful as a therapeutic agent. However, liraglutide has a half-life after subcutaneous injection of 11–15 hours, making it suitable for once-daily dosing (less frequent than the currently approved Byetta form of exenatide, which is twice daily, but considerably more frequent than the once weekly Bydureon form of exenatide, which received marketing approval from the FDA on January 27, 2012).

The prolonged action of liraglutide is achieved by attaching a fatty acid molecule at one position of the GLP-1 molecule, enabling it to bind to albumin within the subcutaneous tissue and bloodstream. The active GLP-1 is then released from albumin at a slow, consistent rate. Binding with albumin also results in slower degradation and reduced elimination of liraglutide from the circulation by the kidneys compared to GLP-1.[citation needed]

Cancer concerns[edit]

On April 2, 2009, an FDA advisory panel reviewed the significance of malignant C-cell carcinoma (also known as medullary thyroid cancer, involving the parafollicular cells of the thyroid gland) and thyroid C-cell focal hyperplasia in rats and mice. Some[who?] say the tumors were caused by a nongenotoxic, specific receptor-mediated mechanism to which rodents are particularly sensitive, whereas nonhuman primates and humans are not.[10][11]

The Victoza label carries a boxed warning:

Because of the uncertain relevance of the rodent thyroid C-cell tumor findings to humans, prescribe Victoza only to patients for whom the potential benefits are considered to outweigh the potential risk.[12]

The FDA said serum calcitonin, a biomarker of medulliary thyroid cancer, was slightly increased in liraglutide patients, but still within normal ranges, and it required ongoing monitoring for 15 years in a cancer registry.[13]

Pancreatitis concerns[edit]

Lotte Bjerre Knudsen, the NovoNordisk scientist who invented liraglutide, acknowledges "(GLP)-1 analogs have been implicated as a risk factor for pancreatitis in humans." [14] However, her team reports "liraglutide did not induce pancreatitis in mice, rats, or monkeys" based on over 1,000 animals.[14] In 2013, UCLA's Dr Alexandra Butler led a team that found "marked expansion" of the pancreas in eight organ donors who had been treated with incretin mimetic drugs such as Victoza and Byetta.[15] The European Medicines Agency [16] has reviewed the data and concluded the drugs should continue to be used. Others such as Public Citizen remain seriously concerned.[17]

Controversy[edit]

In 2010, Novo Nordisk breached the ABPI's code of conduct by failing to provide information about side effects of Victoza, and by promoting Victoza prior to being granted market authorization.[18]

In 2012, the non-profit consumer advocacy group Public Citizen petitioned the U.S. Food and Drug Administration (FDA) to immediately remove liraglutide from the market because they concluded that risks of thyroid cancer and pancreatitis outweigh any documented benefits.[19]

Marketing[edit]

Novo Nordisk has made direct-to-consumer advertising of liraglutide in Sweden (May 2011), through a 6-page supplement in the free newspaper Metro. Although the name of the drug was not explicitly mentioned (this is illegal in the European Union), it could easily be identified through supplied information on dosage and pharmacodynamics.

In January 2012, chef Paula Deen, who is diabetic, and her sons were used in consumer advertising.[20]

See also[edit]

exenatide (Byetta)
albiglutide
taspoglutide

References[edit]

  1. ^ http://www.drugs.com/nda/liraglutide_080530.html May 2008
  2. ^ http://www.medicalnewstoday.com/articles/110349.php "Clinical Study Shows Liraglutide Reduced Blood Sugar, Weight, And Blood Pressure In Patients With Type 2 Diabetes" June 2008
  3. ^ http://www.drugdevelopment-technology.com/projects/liraglutide/
  4. ^ http://www.novonordisk.com/science/about_rd/quarterly_rd_update.asp Oct 2008 Inc results of LEAD 6 extension
  5. ^ http://money.cnn.com/news/newsfeeds/articles/marketwire/0580389.htm January 2009
  6. ^ Hirschler, Ben (January 13, 2010). "UPDATE 1-Novo starts tests on pill version of Victoza drug". Reuters. 
  7. ^ http://diabetes.webmd.com/news/20080924/new-diabetes-drug-liraglutide-works Sept 2008
  8. ^ (www.drugs.com)
  9. ^ http://care.diabetesjournals.org/cgi/content/abstract/32/1/84 "Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes" Diabetes Care. Oct 2008
  10. ^ "Sector Snap: New Diabetes Drugs Under FDA Review". Advantage Business Media. Archived from the original on |archiveurl= requires |archivedate= (help). Retrieved Sep 7, 2013. 
  11. ^ http://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM148659.pdf
  12. ^ Victoza Package Insert Date of Issue: January 2010 Version: 1
  13. ^ N Engl J Med, 362:774
  14. ^ a b http://diabetes.diabetesjournals.org/content/61/5/1243.full
  15. ^ http://diabetes.diabetesjournals.org/content/early/2013/03/17/db12-1686.abstract
  16. ^ http://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2013/07/news_detail_001856.jsp
  17. ^ http://www.citizen.org/pressroom/pressroomredirect.cfm?ID=3850
  18. ^ "Novo Nordisk Limited, Eli Lilly and Company Limited, Grünenthal Ltd and Napp Pharmaceuticals Limited named in advertisements". Prescription Medicines Code of Practice Authority (PMCPA). Retrieved 2011-02-07. 
  19. ^ "Public Citizen to FDA: Pull Diabetes Drug Victoza From Market Immediately". Public Citizen. Retrieved 2013-04-02. 
  20. ^ "Diabetes in a new light".