Leiomyoma

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Leiomyoma
Classification and external resources
Lipoleiomyoma2.jpg
Uterine lipoleiomyoma, a type of leiomyoma. H&E stain.
ICD-10D21, D25 (ILDS D21.M40)
ICD-9218
ICD-O:M8890/0-8894
MedlinePlusdostinex
MeSHD007889
 
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Leiomyoma
Classification and external resources
Lipoleiomyoma2.jpg
Uterine lipoleiomyoma, a type of leiomyoma. H&E stain.
ICD-10D21, D25 (ILDS D21.M40)
ICD-9218
ICD-O:M8890/0-8894
MedlinePlusdostinex
MeSHD007889

A leiomyoma (plural leiomyomas or leiomyomata) (leio- + myo- + -oma, "smooth-muscle tumor") is a benign smooth muscle neoplasm that is very rarely (0.1%) premalignant. They can occur in any organ, but the most common forms occur in the uterus, small bowel and the esophagus.

Leiomyoma enucleated from a uterus. External surface on left; cut surface on right

Uterine leiomyomata[edit]

Main article: Uterine fibroids

Uterine fibroids are leiomyomata of the uterine smooth muscle. As other leiomyomata, they are benign, but may lead to excessive menstrual bleeding (menorrhagia), often cause anemia and may lead to infertility.

A rare form of these tumors is uterine lipoleiomyoma - benign tumors consisting of a mixture of adipocytes and smooth muscle cells. Uterine lipoleiomyomata have been observed together with ovarian and other pathologies and some of them may develop into liposarcoma.[1][2][3] These tumors are monoclonal, and non-random chromosomal abnormalities have been seen in 40% of the tumors.

Gallbladder leiomyoma[edit]

Mesenchymal neoplasms of the gallbladder are rare and in particular leiomyomas of the gallbladder have been rarely reported, all of them in patients with immune system disorders. Although, recently, a case was reported in absence of associated immunodeficiency. [4]

Cutaneous[edit]

Leiomyomas of the skin are generally (1) acquired, and (2) divided into several categories:[5][6]

Leiomyoma of jejunum[edit]

Leiomyoma is the most common benign tumor of small bowel. Approximately 50% of cases are found in the jejunum, followed by the ileum in 31% of cases. Almost one half of all lesions are less than 5 centimeters.[7]

Other locations, metastatic leiomyoma[edit]

See also[edit]

References[edit]

  1. ^ Pedeutour, F.; Quade, B. J.; Sornberger, K.; Tallini, G.; Ligon, A. H.; Weremowicz, S.; Morton, C. C. (2000). "Dysregulation ofHMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14". Genes, Chromosomes and Cancer 27 (2): 209–215. doi:10.1002/(SICI)1098-2264(200002)27:2<209::AID-GCC14>3.0.CO;2-U. PMID 10612811.  edit
  2. ^ McDonald, A. G.; Cin, P. D.; Ganguly, A.; Campbell, S.; Imai, Y.; Rosenberg, A. E.; Oliva, E. (2011). "Liposarcoma Arising in Uterine Lipoleiomyoma". The American Journal of Surgical Pathology 35 (2): 221–227. doi:10.1097/PAS.0b013e31820414f7. PMID 21263242.  edit
  3. ^ Walid MS, Heaton RL. "Case report of a cervical lipoleiomyoma with an incidentally discovered ovarian granulosa cell tumor – imaging and minimal-invasive surgical procedure". GMS Ger Med Sci 8 (26). 
  4. ^ Segura-Sampedro, J. J.; Alamo-Martínez, J. M.; Cañete-Gómez, J.; Suárez-Artacho, G.; González-Cantón, J. R.; Gómez-Bravo, M. Á.; Padillo-Ruiz, F. J. (2012). "Gallbladder leiomyoma in absence of immune system disorders: An unusual diagn". Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 104 (7): 382–384. doi:10.4321/S1130-01082012000700009. PMID 22849501.  edit
  5. ^ Freedberg, Irwin M.; Fitzpatrick, Thomas B. (2003). Fitzpatrick's dermatology in general medicine (6th ed.). New York: McGraw-Hill, Medical Pub. Division. p. 1033. ISBN 0-07-138076-0. 
  6. ^ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology (10th ed.). Saunders Elsevier. p. 627. ISBN 0-7216-2921-0. 
  7. ^ By Michael P. Buetow, M.D. "Leiomyoma of Jejunum". Applied Radiology Online. Retrieved 2007-03-21. 
  8. ^ Patton, K.; Cheng, L.; Papavero, V.; Blum, M.; Yeldandi, A.; Adley, B.; Luan, C.; Diaz, L.; Hui, P.; Yang, X. J. (2006). "Benign metastasizing leiomyoma: clonality, telomere length and clinicopathologic analysis". Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 19 (1): 130–140. doi:10.1038/modpathol.3800504. PMID 16357844.  edit
  9. ^ Beck, M. M.; Biswas, B.; d'Souza, A.; Kumar, R. (2012). "Benign metastasising leiomyoma after hysterectomy and bilateral salpingo-oophorectomy". Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 18 (2): 153–155. PMID 22477740.  edit
  10. ^ Rivera, J. A.; Christopoulos, S.; Small, D.; Trifiro, M. (2004). "Hormonal Manipulation of Benign Metastasizing Leiomyomas: Report of Two Cases and Review of the Literature". Journal of Clinical Endocrinology & Metabolism 89 (7): 3183–3188. doi:10.1210/jc.2003-032021. PMID 15240591.  edit

External links[edit]