Latanoprost

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Latanoprost
Latanoprost.svg
Latanoprost-3D-balls.png
Systematic (IUPAC) name
isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2- [(3R)3-hydroxy-5-phenylpentyl]-cyclopentyl] hept-5-enoate
Clinical data
Trade namesXalatan
AHFS/Drugs.commonograph
MedlinePlusa697003
Pregnancy cat.C (US)
Legal status-only (US)
RoutesTopical (eye drops)
Pharmacokinetic data
Half-life17 minutes
Identifiers
CAS number130209-82-4 YesY
ATC codeS01EE01
PubChemCID 5311221
IUPHAR ligand1961
DrugBankDB00654
ChemSpider4470740 YesY
UNII6Z5B6HVF6O YesY
KEGGD00356 YesY
ChEBICHEBI:6384 YesY
ChEMBLCHEMBL1051 YesY
Chemical data
FormulaC26H40O5 
Mol. mass432.593 g/mol
 YesY (what is this?)  (verify)
 
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Latanoprost
Latanoprost.svg
Latanoprost-3D-balls.png
Systematic (IUPAC) name
isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2- [(3R)3-hydroxy-5-phenylpentyl]-cyclopentyl] hept-5-enoate
Clinical data
Trade namesXalatan
AHFS/Drugs.commonograph
MedlinePlusa697003
Pregnancy cat.C (US)
Legal status-only (US)
RoutesTopical (eye drops)
Pharmacokinetic data
Half-life17 minutes
Identifiers
CAS number130209-82-4 YesY
ATC codeS01EE01
PubChemCID 5311221
IUPHAR ligand1961
DrugBankDB00654
ChemSpider4470740 YesY
UNII6Z5B6HVF6O YesY
KEGGD00356 YesY
ChEBICHEBI:6384 YesY
ChEMBLCHEMBL1051 YesY
Chemical data
FormulaC26H40O5 
Mol. mass432.593 g/mol
 YesY (what is this?)  (verify)

Latanoprost (pronounced la-TA-noe-prost) ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure. It is a prostaglandin analogue (more specifically an analogue of prostaglandin F[1]) that works by increasing the outflow of aqueous fluid from the eyes (through the uvealsclearal tract).[2]

It is also known by the brand name of Xalatan manufactured by Pfizer. Annual sales are approximately $1.6 billion. The patent for latanoprost expired in March 2011, and at least one generic version (manufactured by Mylan Inc.) is now widely available in the U.S. The Veterans Health Administration, part of the U.S. Department of Veterans Affairs, uses generic Latanoprost manufactured by Alcon Laboratories of Fort Worth, Texas distributed by Novartis generic brand Sandoz Pharmaceuticals.

Latanoprost was developed by Carl B. Camras and his research adviser László Z. Bitó at Columbia University in 1996.[3]

Adverse reactions[edit]

Possible side effects:

See also[edit]

References[edit]

  1. ^ Ishikawa H, Yoshitomi T, Mashimo K, Nakanishi M, Shimizu K (February 2002). "Pharmacological effects of latanoprost, prostaglandin E2, and F2alpha on isolated rabbit ciliary artery". Graefes Arch. Clin. Exp. Ophthalmol. 240 (2): 120–5. doi:10.1007/s00417-001-0412-4. PMID 11931077. 
  2. ^ Patel SS, Spencer CM (1996). "Latanoprost. A review of its pharmacological properties, clinical efficacy and tolerability in the management of primary open-angle glaucoma and ocular hypertension". Drugs Aging 9 (5): 363–378. PMID 8922563. 
  3. ^ http://app1.unmc.edu/publicaffairs/todaysite/sitefiles/today_full.cfm?match=5604
  4. ^ Amano S, Nakai Y, Ko A, Inoue K, Wakakura M (2008). "A case of keratoconus progression associated with the use of topical latanoprost". Jpn. J. Ophthalmol. 52 (4): 334–6. doi:10.1007/s10384-008-0554-6. ISBN 38400805546 Check |isbn= value (help). PMID 18773275. 

External links[edit]