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The Killip classification is a system used in individuals with an acute myocardial infarction (heart attack), in order to risk stratify them. Individuals with a low Killip class are less likely to die within the first 30 days after their myocardial infarction than individuals with a high Killip class.
The study was a case series with unblinded, unobjective outcomes, not adjusted for confounding factors, nor validated in an independent set of patients. The setting was the coronary care unit of a university hospital in the USA.
250 patients were included in the study (aged 28 to 94; mean 64, 72% male) with a myocardial infarction. Patients with a cardiac arrest prior to admission were excluded.
Patients were ranked by Killip class in the following way:
The numbers below were accurate in 1967. Nowadays, they have diminished by 30 to 50% in every class.
Within a 95% confidence interval the patient outcome was as follows:
|Killip class I:||81/250 patients;||32% (27–38%).||Mortality rate was found to be 6%.(current 30 day mortality 2.8)|
|Killip class II:||96/250 patients;||38% (32–44%).||Mortality rate was found to be 17%.(current 30 day mortality 8.8)|
|Killip class III:||26/250 patients;||10% (6.6–14%).||Mortality rate was found to be 38%.(current 30 day mortality 14.4)|
|Killip class IV:||47/250 patients;||19% (14–24%).||Mortality rate was found to be 67%.|
The Killip-Kimball classification has played a fundamental role in classic cardiology, having been used as a stratifying criteria for many other studies. Worsening Killip class has been found to be independently associated with increasing mortality in several studies.