Hyser appeared in various films in the early 1980s, the last of which — Just One of the Guys (1985) — achieved some cult status. She then mainly guest-starred in television series, including a recurring role in L.A. Law as Jimmy Smits's girlfriend. Hyser was interested in the role of Dr. Melfi on The Sopranos, but the role went to Lorraine Bracco.
In the early 1990s, Hyser stopped appearing on television in favor of once more making movies and screenwriting.
More recently, Hyser has become a spokeswoman for the Harold Robinson Foundation which provides a free summer camp for inner city and underprivileged children.
Joyce Hyser was featured prominently in the music video for "I Can Dream About You" by Dan Hartman receiving much airtime on MTV in the mid '80s. In the video, Dan Hartman is a bartender pining for a beautiful customer, Joyce Hyser.